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Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (06): 1115-1118. Previous Articles     Next Articles

Reports

氧官能化的膦配体在钯催化的Suzuki-Miyaura反应中的应用

贾莉a，于宏伟b,c，童庆松a，施继成*<sup>,<i>a</i>,<i>c</sup></i>，金子林<i><sup>b</i>   

  1. (<i><sup>a</sup></i>福建师范大学化学与材料学院 福建省高分子材料重点实验室 福州 350007)<br>(<i><sup>b</sup></i>大连理工大学精细化学国家重点实验室 大连 116012)<br>(<i><sup>c</sup></i>中国科学院大连化学物理研究所 大连 116023)
  • 收稿日期:2007-08-21 修回日期:2007-12-20 发布日期:2008-06-26
  • 通讯作者: 施继成

Application of Oxygen-Functionalized Phosphines as Supporting Ligands in the Palladium-Catalyzed Suzuki-Miyaura Reaction

JIA, Lia, YU, Hong-Weib, TONG, Qing-Songa, SHI, Ji-Cheng*,a,c , JIN, Zi-Linb   

  1. (<i><sup>a</sup> Key Laboratory of Polymer Materials of Fujian Province</i>,<i> College of Chemistry and Materials Sci-ence</i>,<i> </i><br><I>Fujian Normal University</i>,<i> Fuzhou 350007</i>)<br>(<i><sup>b</sup> State Key Labora-tory of Fine Chemicals</i>,<i> Dalian University of Technology</i>,<i> Dalian 116012</i>)<br>(<i><sup>c</sup> Dalian Institute of Chemical Physics</i>,<i> Chinese Academy of Sciences</i>,<i> Dalian 116023</i>)<i>
  • Received:2007-08-21 Revised:2007-12-20 Published:2008-06-26
  • Contact: SHI, Ji-Cheng

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Ferrocenyl phosphines with methoxy and hydroxy groups have been synthesized and evaluated as supporting ligands in the palladium-catalyzed Suzuki-Miyaura cross-coupling reaction. It was found that the phosphine having methoxy group as supporting lidand afforded better palladium catalyst with Pd(OAc)<sub>2</sub>, which can catalyze electron-rich aryl bromides and electron-deficient aryl chlorides to couple with phenylboronic acid to form the corresponding biaryls in high yields.

Key words: oxygen-functionalizing, biaryl, Pd catalyst, C—C bond-forming reaction, phosphine