Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Brönsted Acidic Ionic Liquid

doi:10.6023/cjoc1109181

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (05): 962-965.DOI: 10.6023/cjoc1109181 Previous Articles Next Articles

Notes

Brönsted 酸性离子液体催化3,4-二氢嘧啶-2-酮衍生物的合成

刘伟华, 高书涛, 冯成, 臧晓欢, 周欣, 马晶军, 王春

河北农业大学理学院保定 071001

收稿日期:2011-09-18 修回日期:2011-12-03 发布日期:2012-01-04
通讯作者: 王春 E-mail:wangc69@yahoo.com.cn
基金资助:
河北省自然科学基金(No. B2011204051)和河北农业大学理工基金(No. LG201107)资助项目.

Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Brönsted Acidic Ionic Liquid

Liu Weihua, Gao Shutao, Feng Cheng, Zang Xiaohuan, Zhou Xin, Ma Jingjun, Wang Chun

College of Science, Agricultural University of Hebei, Baoding 071001

Received:2011-09-18 Revised:2011-12-03 Published:2012-01-04
Supported by:
Project supported by the Natural Science Foundation of Hebei Province (No. B2011204051) and the Science and Engineering Foundation of Agricultural University of Hebei Province (No. LG201107).

A series of 3,4-dihydropyrimidin-2(1H)-ones were prepared through the Biginelli condensation reactions of aromatic aldehydes, keto ester and urea catalyzed by Brönsted acidic ionic liquid 3-methyl-1-(3-sulfopropyl)-imidazolium trifluoroacetate under solvent free conditions. The method is simple, solvent free, high yields and environmental friendly. The catalyst could be recycled and reused. The reactions were carried out in boiling water bath for 30～40 min. The yields of the products were between 81%～94%. All the products have been characterized by ¹H NMR and IR spectra.

Key words: Brönsted acid-based ionic liquids, 3,4-dihydropyrimidin-2(1H)-one, synthesis

Cite this article

Liu Weihua, Gao Shutao, Feng Cheng, Zang Xiaohuan, Zhou Xin, Ma Jingjun, Wang Chun. Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Brönsted Acidic Ionic Liquid[J]. Chin. J. Org. Chem., 2012, 32(05): 962-965.

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Brönsted 酸性离子液体催化3,4-二氢嘧啶-2-酮衍生物的合成

Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Brönsted Acidic Ionic Liquid

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