Synthesis and Antifungal Activity of Novel Substituted- 3-aryl-1,2,4-triazolo[3,4-b]benzothiazoles

doi:10.6023/cjoc1111162

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (05): 957-961.DOI: 10.6023/cjoc1111162 Previous Articles Next Articles

Notes

新型取代3-芳基-1,2,4-三唑并[3,4-b]苯并噻唑的合成及其杀菌活性

翁建全^a, 黄华^a, 谭成侠^a, 刘幸海^a, 储为盛^a, 陈杰^b

a 浙江工业大学化学工程与材料学院杭州 310032;
b 国家南方农药创制中心浙江基地生测部杭州 310023

收稿日期:2011-10-16 修回日期:2011-12-13 发布日期:2012-01-06
通讯作者: 翁建全 E-mail:jqweng@zjut.edu.cn
基金资助:
国家自然科学基金(No. 30900959)资助项目.

Synthesis and Antifungal Activity of Novel Substituted- 3-aryl-1,2,4-triazolo[3,4-b]benzothiazoles

Weng Jianquan^a, Huang Hua^a, Tan Chengxia^a, Liu Xinghai^a, Chu Weisheng^a, Chen Jie^b

a College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310032;
b Bioassay Department, Zhejiang Branch of National Southern Pesticide Research Centre, Hangzhou 310023

Received:2011-10-16 Revised:2011-12-13 Published:2012-01-06
Supported by:
Project supported by the National Natural Science Foundation of China (No. 30900959).

In order to find new benzothiazole lead compounds, eighteen new substitued-3-aryl-1,2,4-triazolo[3,4-b]-benzothiazoles were synthesized by reacting substituted-2-hydrazinobenzothiazole with various substituted benzoic acids in POCl3 under reflux condition. The structures of the title compounds were characterized by ¹H NMR, EIMS techniques and elemental analysis. The preliminary bioassy results indicated that some of them showed moderate inhibition activity against Rhizoctonia solani, Ascochyta citrullina, Fusarium oxysporum f.sp. cubense and Colletotrichum nicotianae. Unexpectedly, some of them possessed certain promotion activity against Botrytis cinerea.

Key words: 1,2,4-triazolo[3,4-b]benzothiazole, synthesis, antifungal activity

Cite this article

Weng Jianquan, Huang Hua, Tan Chengxia, Liu Xinghai, Chu Weisheng, Chen Jie. Synthesis and Antifungal Activity of Novel Substituted- 3-aryl-1,2,4-triazolo[3,4-b]benzothiazoles[J]. Chin. J. Org. Chem., 2012, 32(05): 957-961.

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新型取代3-芳基-1,2,4-三唑并[3,4-b]苯并噻唑的合成及其杀菌活性

Synthesis and Antifungal Activity of Novel Substituted- 3-aryl-1,2,4-triazolo[3,4-b]benzothiazoles

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