Copper Catalyzed Synthesis of Quinazolin-4(3H)-ylidene Derivatives Containing Carbonyl and Ester Group at Room Temperature

doi:10.6023/cjoc201402009

Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (10): 2076-2082.DOI: 10.6023/cjoc201402009 Previous Articles Next Articles

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室温下铜催化制备含羰基或酯基的喹唑啉-4(3H)-亚基类衍生物

谢瑞龙, 杨新玲, 秦耀果, 谭晓庆, 凌云

中国农业大学理学院应用化学系农业部农药化学及应用重点开放实验室北京 100193

收稿日期:2014-02-08 修回日期:2014-04-28 发布日期:2014-06-03
通讯作者: 凌云 E-mail:lyun@cau.edu.cn
基金资助:
国家自然科学基金（No. 21272266）和国家“十二五”科技支撑计划课题（No. 2011BAE06B05-5）资助项目.

Copper Catalyzed Synthesis of Quinazolin-4(3H)-ylidene Derivatives Containing Carbonyl and Ester Group at Room Temperature

Xie Ruilong, Yang Xinling, Qin Yaoguo, Tan Xiaoqing, Ling Yun

Key Laboratory of Pesticide Chemistry and Application, Ministry of Agriculture, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193

Received:2014-02-08 Revised:2014-04-28 Published:2014-06-03
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21272266) and the National "Twelfth Five-Year" Plan for Science & Technology (No. 2011BAE06B05-5).

At room temperature, a new simple and efficient copper-catalyzed method for the synthesis of quinazolin- 4(3H)-ylidene derivatives containing carbonyl and ester group was developed. The targets were prepared using methyl 3-(2-bromophenyl)-3-oxopropanoate analogues and amidine hydrochlorides as the initial materials, cuprous iodide as catalyst, and potassium phosphate as base at the ligand-free condition. Their structures were confirmed by ¹H NMR, ¹³C NMR and HRMS.

Key words: copper, room temperature, catalyst, quinazoline

Cite this article

Xie Ruilong, Yang Xinling, Qin Yaoguo, Tan Xiaoqing, Ling Yun. Copper Catalyzed Synthesis of Quinazolin-4(3H)-ylidene Derivatives Containing Carbonyl and Ester Group at Room Temperature[J]. Chin. J. Org. Chem., 2014, 34(10): 2076-2082.

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室温下铜催化制备含羰基或酯基的喹唑啉-4(3H)-亚基类衍生物

Copper Catalyzed Synthesis of Quinazolin-4(3H)-ylidene Derivatives Containing Carbonyl and Ester Group at Room Temperature

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