Asymmetric Synthesis of Spirooxindoles via Organocascade Strategies

doi:10.6023/cjoc201504045

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (10): 2035-2048.DOI: 10.6023/cjoc201504045 Previous Articles Next Articles

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通过串联反应不对称合成氧化吲哚螺环化合物的研究进展

肖永龙^a, 周宇^b, 王江^b, 王进欣^a, 柳红^b

a 中国药科大学江苏省药物分子设计与成药性优化重点实验室南京 210009;
b 中国科学院上海药物研究所受体结构与功能重点实验室上海 201302

收稿日期:2015-04-28 修回日期:2015-06-16 发布日期:2015-07-02
通讯作者: 王进欣, 柳红 E-mail:jinxinwang@163.com;hliu@mail.shcnc.ac.cn
基金资助:
国家自然科学基金(No. 21372235)资助项目.

Asymmetric Synthesis of Spirooxindoles via Organocascade Strategies

Xiao Yonglong^a, Zhou Yu^b, Wang Jiang^b, Wang Jinxin^a, Liu Hong^b

a Jiangsu Province Key Laboratory of Drug Design and Optimization Medicine, China Pharmaceutical University, Nanjing 210009;
b CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203

Received:2015-04-28 Revised:2015-06-16 Published:2015-07-02
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21372235).

The spirooxindoles have broad and promising activities in various therapeutic areas, and become a privileged skeleton for drug discovery. Therefore, the development of some simple and efficient strategies to build these sophisticated scaffolds has become one of the most widespread concerns. However, the traditional methods are limited by the separation and purification of intermediates, the functional group protection and de-protection. Recently, the cascade strategies have shown special advantages in the synthesis of optically active natural products and complex molecules, many related studies have been reported. This review summarizes the enantioselective synthesis of spirooxindoles via cascade strategies in the past five years and organized on the basis of four types of starting materials: unsaturated oxindole derivatives, C(3)-substituted oxindoles, C(3)-unsubstituted oxindoles and nonoxindoles.

Key words: spirooxindoles, asymmetric, catalysis, organocascade

Cite this article

Xiao Yonglong, Zhou Yu, Wang Jiang, Wang Jinxin, Liu Hong. Asymmetric Synthesis of Spirooxindoles via Organocascade Strategies[J]. Chin. J. Org. Chem., 2015, 35(10): 2035-2048.

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通过串联反应不对称合成氧化吲哚螺环化合物的研究进展

Asymmetric Synthesis of Spirooxindoles via Organocascade Strategies

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