Advances in Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones

doi:10.6023/cjoc201903025

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (9): 2392-2402.DOI: 10.6023/cjoc201903025 Previous Articles Next Articles

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2,3-二氢喹唑啉-4(1H)-酮类化合物的合成研究进展

张晓鹏, 朱妍洁, 朱奕崧, 李政伟, 张贵生

河南师范大学化学化工学院绿色化学介质与反应教育部重点实验室河南省有机功能分子与药物创新重点实验室精细化学品绿色制造河南省协同创新中心新乡 453007

收稿日期:2019-03-14 修回日期:2019-04-11 发布日期:2019-04-26
通讯作者: 张晓鹏 E-mail:zhangxiaopengv@sina.com
基金资助:
国家自然科学基金（Nos.21772033，U1604285）、高等学校学科创新引智计划（111计划，No.D17007）资助项目.

Advances in Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones

Zhang Xiaopeng, Zhu Yanjie, Zhu Yisong, Li Zhengwei, Zhang Guisheng

Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007

Received:2019-03-14 Revised:2019-04-11 Published:2019-04-26
Contact: 10.6023/cjoc201903025 E-mail:zhangxiaopengv@sina.com
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21772033, U1604285) and the Program of Introducing Talents of Discipline to Universities (111 Project, No. D17007).

2,3-Dihydroquinazolin-4(1H)-one compounds are an important class of nitrogen-containing fused heterocycles, which possess a wide range of pharmacological and biological activities and have important applications in the fields of synthesis and research & development of drugs. Therefore, its synthetic methods have also attracted considerable attention. In this paper, the main advances in the synthesis of 2,3-dihydroquinazolin-4(1H)-ones and their proposed reaction mechanisms from the raw materials such as o-aminobenzamides, isatoic anhydrides, o-nitrobenzamides, o-azidobenzamide, o-bromo-benzamide, o-bromobenzonitrile, o-aminobenzoic acids, o-aminobenzonitrile, o-amino-N-(propa-1,2-dienyl)benzamides, and N-alkyl anilines were introduced and reviewed, respectively. Finally, the synthesis of these compounds was summarized and the prospect of their development was prospected.

Key words: 2,3-dihydroquinazolin-4(1H)-one, o-aminobenzamides, isatoic anhydrides, N-alkyl anilines, C-H activation &, functionalization, palladium catalysis

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Zhang Xiaopeng, Zhu Yanjie, Zhu Yisong, Li Zhengwei, Zhang Guisheng. Advances in Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones[J]. Chin. J. Org. Chem., 2019, 39(9): 2392-2402.

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2,3-二氢喹唑啉-4(1H)-酮类化合物的合成研究进展

Advances in Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones

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