A Fluorescent Probe for Hydrazine Based on Synergistic Effect and Its Utilization in Cell Imaging

doi:10.6023/cjoc201907039

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (1): 181-185.DOI: 10.6023/cjoc201907039 Previous Articles Next Articles

一种基于协同效应的肼荧光探针及其在细胞成像中的应用

胥稳智, 李雪, 韩孟楠, 周婷婷, 杨瑜涛, 李玮

河北大学化学与环境科学学院药物化学与分子诊断教育部重点实验室河北省化学生物学重点实验室河北保定 071002

收稿日期:2019-07-26 修回日期:2019-08-28 发布日期:2019-09-25
通讯作者: 胥稳智, 李玮 E-mail:wzxu2008@sinano.ac.cn;liweihebeilab@163.com
基金资助:
国家自然科学基金（Nos.21702043，21807021）资助项目.

A Fluorescent Probe for Hydrazine Based on Synergistic Effect and Its Utilization in Cell Imaging

Xu Wenzhi, Li Xue, Han Mengnan, Zhou Tingting, Yang Yutao, Li Wei

Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry & Environmental Science, Hebei University, Baoding, Hebei 071002

Received:2019-07-26 Revised:2019-08-28 Published:2019-09-25
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21702043, 21807021).

1. 200181S.pdf.pdf(969KB)

Abstract

Hydrazine is an important raw material and catalyst in chemical industry. However, hydrazine is very harmful to human organs. A new type of probe was developed based on the synergistic effect. Two recognition sites were introduced into the probe to improve performance to hydrazine, which has good specificity to hydrazine. The limit of detection (LOD) for N₂H₄ was 0.05~10.0 μmol·L^-1. Moreover, the probe could detect N₂H₄ in BT-474 cells.

Key words: hydrazine, synergistic effect, cell imaging, fluorescent probe

Cite this article

Xu Wenzhi, Li Xue, Han Mengnan, Zhou Tingting, Yang Yutao, Li Wei. A Fluorescent Probe for Hydrazine Based on Synergistic Effect and Its Utilization in Cell Imaging[J]. Chinese Journal of Organic Chemistry, 2020, 40(1): 181-185.

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一种基于协同效应的肼荧光探针及其在细胞成像中的应用

A Fluorescent Probe for Hydrazine Based on Synergistic Effect and Its Utilization in Cell Imaging

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