Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (5): 1387-1395.DOI: 10.6023/cjoc202203053 Previous Articles Next Articles
Special Issue: 有机氟化学虚拟合辑
ARTICLES
刘冰a,*(
), 王智传a, 孙凯b, 唐石c, 王薪b,*()
收稿日期:2022-03-27
修回日期:2022-04-03
发布日期:2022-04-14
通讯作者:
刘冰, 王薪
基金资助:
Bing Liua(), Zhichuang Wanga, Kai Sunb, Shi Tangc, Xin Wangb()
Received:2022-03-27
Revised:2022-04-03
Published:2022-04-14
Contact:
Bing Liu, Xin Wang
Supported by:Share
Bing Liu, Zhichuang Wang, Kai Sun, Shi Tang, Xin Wang. Silver-Mediated Radical Trifluoromethylthiolation Cyclization: Synthesis of CF3S-Containing Benzimidazole[2,1-a]isoquinolines[J]. Chinese Journal of Organic Chemistry, 2022, 42(5): 1387-1395.
| Entry | Oxidant/equiv. | Additive/equiv. | V(solvent)/ mL | Yield/% |
|---|---|---|---|---|
| 1 | K2S2O8 (2.0) | None | DMSO | 52 |
| 2 | K2S2O8 (2.0) | None | MeCN | 17 |
| 3 | K2S2O8 (2.0) | None | DCE | 0 |
| 4 | K2S2O8 (2.0) | None | THF | 21 |
| 5 | K2S2O8 (1.0) | None | DMSO | 50 |
| 6 | PIDA (1.0) | None | DMSO | 38 |
| 7 | Selectfluor (1.0) | None | DMSO | 0 |
| 8 | TBHP (1.0) | None | DMSO | Trace |
| 9 | (NH4)2S2O8 (1.0) | None | DMSO | 51 |
| 10 | K2S2O8 (1.0) | KH2PO4 (1.5) | DMSO | 62 |
| 11 | K2S2O8 (1.0) | HMPA (1.5) | DMSO | Trace |
| 12 | K2S2O8 (1.0) | Li2CO3 (1.5) | DMSO | 35 |
| 13 | K2S2O8 (1.0) | NaHCO3 (1.5) | DMSO | 48 |
| 14 | K2S2O8 (1.0) | KHCO3 (1.5) | DMSO | 47 |
| 15 | K2S2O8 (1.0) | Na2CO3 (1.5) | DMSO | 50 |
| 16 | K2S2O8 (1.0) | DBU (1.5) | DMSO | 53 |
| 17 | K2S2O8 (1.0) | KH2PO4·3H2O (1.5) | DMSO | 65 |
| 18 | K2S2O8 (1.0) | KH2PO4·3H2O (1.0) | DMSO | 83 |
| 19 | K2S2O8 (1.0) | KH2PO4·3H2O (0.5) | DMSO | 64 |
| 20 | K2S2O8 (1.0) | KH2PO4·3H2O (1.0) | DMSO | 56c |
| 21 | K2S2O8 (1.0) | KH2PO4·3H2O (1.0) | DMSO | 70d |
| Entry | Oxidant/equiv. | Additive/equiv. | V(solvent)/ mL | Yield/% |
|---|---|---|---|---|
| 1 | K2S2O8 (2.0) | None | DMSO | 52 |
| 2 | K2S2O8 (2.0) | None | MeCN | 17 |
| 3 | K2S2O8 (2.0) | None | DCE | 0 |
| 4 | K2S2O8 (2.0) | None | THF | 21 |
| 5 | K2S2O8 (1.0) | None | DMSO | 50 |
| 6 | PIDA (1.0) | None | DMSO | 38 |
| 7 | Selectfluor (1.0) | None | DMSO | 0 |
| 8 | TBHP (1.0) | None | DMSO | Trace |
| 9 | (NH4)2S2O8 (1.0) | None | DMSO | 51 |
| 10 | K2S2O8 (1.0) | KH2PO4 (1.5) | DMSO | 62 |
| 11 | K2S2O8 (1.0) | HMPA (1.5) | DMSO | Trace |
| 12 | K2S2O8 (1.0) | Li2CO3 (1.5) | DMSO | 35 |
| 13 | K2S2O8 (1.0) | NaHCO3 (1.5) | DMSO | 48 |
| 14 | K2S2O8 (1.0) | KHCO3 (1.5) | DMSO | 47 |
| 15 | K2S2O8 (1.0) | Na2CO3 (1.5) | DMSO | 50 |
| 16 | K2S2O8 (1.0) | DBU (1.5) | DMSO | 53 |
| 17 | K2S2O8 (1.0) | KH2PO4·3H2O (1.5) | DMSO | 65 |
| 18 | K2S2O8 (1.0) | KH2PO4·3H2O (1.0) | DMSO | 83 |
| 19 | K2S2O8 (1.0) | KH2PO4·3H2O (0.5) | DMSO | 64 |
| 20 | K2S2O8 (1.0) | KH2PO4·3H2O (1.0) | DMSO | 56c |
| 21 | K2S2O8 (1.0) | KH2PO4·3H2O (1.0) | DMSO | 70d |
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