Research Progress of Multi-signal Fluorescent Probes for Simultaneous Detection of Biothiols

doi:10.6023/cjoc202210034

Abstract

There is a close relationship between different biothiols. The changes of one biothiol level in a specific cell metabolism process may be related to the variation of another biothiol, and many diseases are the result of the combination of two or more biothiols. The simultaneous detection of divers biological thiols by fluorescence method is of particular importance for biological research and disease diagnosis. In recent years, breakthrough results have been achieved in this field. The research progress of multi-signal fluorescent probes in the field of simultaneous detection of biothiols is reviewed. According to the objects detected by the probes, the fluorescent probes are systemically classified and discussed, and the corresponding design concept, optical properties, detection mechanism, recognition performance and biological applications are summarized. At the same time, the future development and application in this field are proposed.

Key words: biothiol, fluorescent probe, simultaneous detection, multi-signal

Cite this article

Tiantian Liu, Hongpeng Zhang, Xiaomeng Jiao, Yinjuan Bai. Research Progress of Multi-signal Fluorescent Probes for Simultaneous Detection of Biothiols[J]. Chinese Journal of Organic Chemistry, 2023, 43(6): 2081-2095.

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Fig. & Tab. 21

Scheme 1. Mechanism of reaction between probe and thiol with “aromatic nucleophilic substitution-rearrangement”

Scheme 2. Probe 1 for distinguishing GSH and Cys/Hcy

Scheme 3. Probes 15 and 16 for distinguishing GSH and Cys/Hcy

Scheme 4. Probe 17 for distinguishing GSH and Cys/Hcy

Scheme 5. Probes 18~23 for distinguishing GSH and Cys/Hcy

Scheme 6. Probes 24 and 25 for distinguishing GSH and Cys/Hcy

Scheme 7. Mechanism of reaction between probe and thiol with “aromatic nucleophilic substitution-addition”

Scheme 8. Probes 26 and 27 for distinguishing GSH and Cys/Hcy

Scheme 9. Probe 30 for distinguishing GSH and Cys/Hcy

Scheme 10. Probes 31~33 for distinguishing GSH and Cys/ Hcy

Scheme 11. Probe 34 for distinguishing Cys and Hcy/GSH

Scheme 12. Probe 35 for distinguishing Cys and Hcy/GSH

Scheme 13. Probe 36 for distinguishing Cys and Hcy/GSH

Scheme 14. Probe 37 for distinguishing Cys and Hcy/GSH

Scheme 15. Probe 38 for distinguishing Cys and Hcy/GSH

Scheme 16. Probe 39 for distinguishing Hcy and Cys/GSH

Scheme 17. Probe 40 for distinguishing Hcy and Cys/GSH

Scheme 18. Probe 41 for distinguishing Cys, Hcy and GSH

Scheme 19. Probes 42~44 for distinguishing Cys, Hcy and GSH

Scheme 20. Probe 45 for distinguishing Cys, Hcy and GSH

Scheme 21. Probe 46 for distinguishing Cys, Hcy and GSH

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