Recent Progress of Aggregation-Induced Emission Molecule Nanozyme Composites

doi:10.6023/cjoc202403040

Abstract

Aggregation-induced emission (AIE) molecule is the most prominent molecule in the fluorescent materials in recent years, and it has high luminous quantum efficiency and excellent capability to produce active oxygen species in the aggregated state. Nanozyme is a kind of nanomaterial with enzyme-like catalytic performance, which has good biocompatibility and excellent enzymatic catalytic activity. The nanocomposites combined with AIE molecule and nanozyme have the unique properties of AIE molecules and nanozyme. In this paper, the preparation of AIE molecule and nanozyme composites and the latest research achievements in the field of chem/biosensing and optical diagnosis and treatment are reviewed. Finally, the shortcomings and future development are also prospected.

Key words: aggregation-induced emission, nanozyme, chem/biosensing, optical diagnosis and treatment

Cite this article

Jie Zhang, Nan Li, Na Zhao. Recent Progress of Aggregation-Induced Emission Molecule Nanozyme Composites[J]. Chinese Journal of Organic Chemistry, 2024, 44(8): 2469-2478.

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Fig. & Tab. 9

Figure 1. (A) Schematic diagram of the overall design of the enzyme cascade activation system AOX/CeO2@TPE＋OPD in response to CH3SH in a proportional fluorimetric colorimetric dual mode, (B) structural formula of TPE, (C) quantitative curves of G/B and CH3SH concentrations in visual colorimetric model and (D) quantitative curves of G/B and CH3SH concentrations in fluorescence model[67] Copyright 2023, American Chemical Society

Figure 3. (A) Schematic diagram of PMD in in situ interventional photodynamic therapy for colon cancer, (B) structural formula of DCPy, (C) in vitro images of tumor and organ collection of CT26 tumor bearing mice in situ 6 h after PMD injection and (D) endoscope localization of tumor in abdominal cavity and initiation of PDT therapy through optical fiber using laser[72] Copyright 2022, American Chemical Society

Figure 4. (A) Schematic diagram of the cascade reaction of Lipo-OGzyme-AIE, (B) structural formula of the AIE molecule and (C) the dynamic change of dissolved O2 levels at different pH values in H2O2 solution of 100 μmol/L, and the decomposition rate of ABDA of Lipo-AIE and Lipo-OGzyme-AIE under white light irradiation[73] Copyright 2019, Elsevier Ltd.

Figure 5. (A) Schematic diagram of BTZ/Fe2＋@BTF/ALD for NIR-II PTT/chemotherapy/CDT in breast cancer with bone metastases, (B) structural formula of BBT-FT-DA and (C) NIR FL image and PA image of mice injected with BTZ/Fe2＋@BTF/ALD by tail vein[74] Copyright 2022, Advanced Science published by Wiley-VCH GmbH

Figure 6. (A) Schematic diagram of cuproptosis induced by PTC, (B) structural formula of TBP-2 and (C) lung tissue collected from mice after treatment under different conditions (blue arrows indicate metastatic lesions)[75] Copyright 2023, American Chemical Society

Figure 7. (A) Schematic diagram of the preparation process of Zn@MOF-TPD and its mechanism for accelerating recovery after spinal cord injury, (B) representative images of stained oxidative stress in mice after different treatments and (C) macro photos of spinal cord injury 2 months after treatment (the white arrow indicates the location of the damaged spinal cord in the enlarged image)[76] Copyright 2024, American Chemical Society.

Figure 8. (A) Schematic diagram of ARC preparation process and its tumor therapy, (B) in vitro ARC CQu release profile in the presence and absence of 808 nm laser irradiation (red arrows being used to indicate irradiation time points) and (C) fluorescence images for mice after intratumoral ARC or PB＋CQu injection 1, 24 and 48 h[77] Copyright 2019, Elsevier Ltd.

Figure 9. (A) Synthesis diagram of 2TT-mC6B@Cu5.4O NPs, (B) structural formula structure of 2TT-mC6B, and (C) schematic diagram of 2TT-mC6B@Cu5.4O NPs for deep infection healing and inflammation inhibition[78] Copyright 2023, Wiley-VCH GmbH

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