Recent Advance in Radical-Mediated Functionalization of Alkenes via Dual C-H Bond Conversion

doi:10.6023/cjoc202512049

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自由基介导双C-H键转化的烯烃官能团化反应研究进展

于琛^a, 李宁^a, 薛琦^a, 李杨^a,*, 汪苇航^b,*, 李金恒^a,c,*

^a青岛科技大学化工学院青岛 266042;
^b湖南省病毒性肝炎临床医学研究中心中南大学湘雅二医院感染科长沙 410011;
^c河南师范大学化学化工学院新乡 453007

收稿日期:2025-01-31 修回日期:2026-02-04

Recent Advance in Radical-Mediated Functionalization of Alkenes via Dual C-H Bond Conversion

Yu Chen^a, Li Ning^a, Xue Qi^a, Li Yang^a,*, Wang Weihang^b,*, Li Jinheng^a,c,*

^aCollege of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042;
^bClinical Research Center For Viral Hepatitis In Hunan Province Changsha, Department of Infectious Diseases, The Second Xiangya Hospital of Central South University, Central South University, Changsha 410011;
^cSchool of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, 453007

Received:2025-01-31 Revised:2026-02-04
Contact: *E-mail: liyang1989@hnu.edu.cn, 218202047@csu.edu.cn, jhli@hnu.edu.cn
Supported by:
National Natural Science Foundation of China (No 22001108 and 22271245), Jiangxi Province Science and Technology Project (no. 20243BCE51084 and 20242BAB25126), Taishan Scholars Construction Projects of Shandong (tsqn202408199) and the Open Research Fund of School of Chemistry and Chemical Engineering, Henan Normal University (No. 2021ZD01).

As a fundamental structural unit of organic compounds, the direct transformation of C-H bond has long been one of the core research topics in organic chemistry. These radical reactions exhibit significant advantages in transformation of C-H bond due to their high reactivity and excellent functional group tolerance, attracting extensive attention from chemists. In particular, radical-mediated functionalization of alkenes via dual C-H bond conversion has undergone rapid development and emerged as a powerful tool for the efficient construction of complex molecules. Herein, we summarize recent advance in radical-mediated functionalization of alkenes via dual C-H bond conversion, categorized by three distinct pathways: C(sp³)-H/C(sp²)-H, C(sp²) -H/C(sp²)-H and C(sp³)-H/C(sp³)-H transformations. This review highlights reaction mechanisms, substrate scope, and further presents an outlook on the future application potential of this research area.

Key words: Radical, Alkene, C-H bond, Alkene difunctionalization

Cite this article

Yu Chen, Li Ning, Xue Qi, Li Yang, Wang Weihang, Li Jinheng. Recent Advance in Radical-Mediated Functionalization of Alkenes via Dual C-H Bond Conversion[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202512049.

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自由基介导双C-H键转化的烯烃官能团化反应研究进展

Recent Advance in Radical-Mediated Functionalization of Alkenes via Dual C-H Bond Conversion

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