Research Progress on the Functionalization of [1.1.1]Propellane via Radical Pathways

doi:10.6023/cjoc202512007

Abstract

Bicyclo[1.1.1]pentane (BCP), a three-dimensional bridged ring scaffold, has been widely used in medicinal chemistry due to its role as a bioisostere for groups such as benzene rings, tert-butyl groups, and alkynes. Currently, the radical ring-opening reaction of [1.1.1]propellane has become the most common strategy for constructing BCP derivatives. Traditional radical functionalization of [1.1.1]propellane typically requires harsh conditions and exhibits poor functional group compatibility. In recent years, with the rapid development of photocatalysis in organic synthesis, various photocatalytic functionalization of [1.1.1]propellane have been reported and successfully applied in the synthesis of drug molecules. This review aims to provide a concise overview of recent advances in radical-based functionalization of [1.1.1]propellane.

Key words: [1.1.1]propellane, bicyclo[1.1.1]pentane, radical, photocatalysis, functionalization

Cite this article

Dong Jianyang, Xue Dong. Research Progress on the Functionalization of [1.1.1]Propellane via Radical Pathways[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202512007.

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自由基途径的[1.1.1]螺桨烷官能化研究进展