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About the Cover:The research progress on reductive acylation with acyl- Ni as a key intermediate to synthesize ketones is reviewed by Qi, Lin, and Chen on page 3861. This review focuses on the recent advances in Ni-catalyzed reductive acylation of various carbon electrophiles with a broad range of carboxylic acids or carboxylic acid derivatives. -
About the Cover:The syntheses of a series of α-methylene-γ-butyrola- ctone derivatives are reported by Shen, Li, Guo, Xie and Nan on page 3916, as novel GPR52 antagonists, which are designed by simplification of natural product E7. These novel α-methylene-γ-butyrolactone derivatives are potential in the treatment of Huntingdon’s disease. -
About the Cover:Asymmetric dearomatization reaction is an important strategy for the preparation of chiral molecules, drugs, and natural products. The dearomatization reactions induced by chiral hypervalent iodine reagents in the past 20 years are summarized by Zhang, Xu, Tang, and Shi on page 3784. Each type of these chiral reagents is in-troduced in detail from the aspect of preparation, asym-metric reactions, and typical examples. In addition, their application in the total synthesis of natural products is also summarized.
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