过渡金属催化芳香烃C-H活化/C-O键偶联反应的研究进展

doi:10.6023/cjoc201706006

摘要/Abstract

C-H活化直接从C-H键出发，不需要对底物进行预先官能团化就能够直接构建C-O键，具有简单快速、原子经济等特点.过渡金属催化的芳香烃C-H活化/C-O偶联反应已成为构建酚、芳基醚和酚酯等多种有机化合物的重要方法，是当前有机化学的研究热点之一.按照不同种类的过渡金属（钯、铜、钌和钴等）和反应类型进行分类，综述了近年来过渡金属催化的芳香烃C-H活化/C-O偶联反应的研究进展，并对代表性反应的机理做了简要说明和比较.另外，对这一领域目前所存在的问题和局限性进行分析，并对未来的发展方向进行了展望.

关键词: C-H键活化, C-O键偶联, 酚, 芳基醚, 酚酯

Transition metal catalyzed C-H activation/C-O coupling reaction of arenes serves as a powerful strategy for constructing phenols, aryl ethers and phenolic esters, and thus represents a hot topic in the field of organic chemistry. This strategy is effective and atom-economic as it allows people to construct C-O bond directly from arenes, avoiding pre-functionalization of arenes. Recent development on transition metal catalyzed C-H activation/C-O coupling reactions according to different species of transition metal catalysts is summarized. Possible mechanisms of typical protocols are explained and compared. Existing problems and limitations, and a brief outlook in this field is also presented.

Key words: C-H activation, C-O coupling, phenol, aryl ether, phenolic ester

引用此文

丁怀伟, 李娟, 郭庆辉, 肖琰. 过渡金属催化芳香烃C-H活化/C-O键偶联反应的研究进展[J]. 有机化学, 2017, 37(12): 3112-3129.

Ding Huaiwei, Li Juan, Guo Qinghui, Xiao Yan. Research Progress on Transition-Metal-Catalyzed C-H Activation/C-O Coupling Reaction of Arenes[J]. Chin. J. Org. Chem., 2017, 37(12): 3112-3129.

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