有机化学 ›› 2020, Vol. 40 ›› Issue (8): 2221-2231.DOI: 10.6023/cjoc202003039 上一篇    下一篇

综述与进展

以二氧化碳为C1合成子的羧基化/环化反应研究进展

周聪, 李渺, 于金涛, 孙松, 成江   

  1. 常州大学石油化工学院 江苏常州 213164
  • 收稿日期:2020-03-15 修回日期:2020-05-13 发布日期:2020-05-15
  • 通讯作者: 孙松, 成江 E-mail:sunsong@cczu.edu.cn;chengjiang@cczu.edu.cn
  • 基金资助:
    国家自然科学基金(Nos.21602019,21971025)、江苏省绿色催化材料与技术重点实验室(No.BM2012110)和江苏省先进催化与绿色制造协同创新中心资助项目.

Recent Progress in the Carboxylation/Cyclization Reactions Using Carbon Dioxide as the C1 Source

Zhou Cong, Li Miao, Yu Jintao, Sun Song, Cheng Jiang   

  1. School of Petrochemical Engineering, Changzhou University, Changzhou, Jiangsu 213164
  • Received:2020-03-15 Revised:2020-05-13 Published:2020-05-15
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21602019, 21971025), the Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology (No. BM2012110) and the Advanced Catalysis and Green Manufacturing Collaborative Innovation Center.

二氧化碳具有价廉易得、储量丰富及无毒等优点,在有机合成反应中是一种理想的C1合成子.近年来,以二氧化碳作为羰基/羧基源,通过环化反应,特别是多组分环化反应构建含羰基杂环化合物,已经取得了重要的研究进展.主要总结了利用含氮、氧亲核原子的试剂与常压条件下二氧化碳的环化反应构建苯并噁嗪、环碳酸酯、内酰胺、2,4-二噁唑啉酮等含羰基杂环结构的工作;其次,也总结了利用含碳亲核原子的试剂与二氧化碳羧基化反应的相关工作.

关键词: 二氧化碳, 多组分反应, 环化反应, 羧酸, 杂环化合物

Carbon dioxide is a readily available, low-cost, abundant, non-toxic C1 source, which can potentially serve as an ideal building block in synthetic chemistry. Recently, much progress, expecially multi-component reactions (MCRs) has been achieved in construction of carbonyl-containing heterocycles through annulation by using carbon dioxide as carbonyl/carboxyl source. Herein, the advances on the annulation reaction of atmospheric CO2 with N-, and O-nucleophiles for the constructioin of various carbonyl-containing heterocycles, including benzoxazin, cyclic carbamates, lactams, oxazolidine-2,4-diones are reviewed. In addition, the carboxylation of C-nucleophiles with CO2 toward carboxylic acids is also summarized.

Key words: carbon dioxide, multicomponent reaction, annulation, carboxylic acid, heterocycle