方酰胺催化的不对称串联反应合成螺环氧吲哚衍生物研究进展

doi:10.6023/cjoc202005065

摘要/Abstract

手性螺环氧吲哚广泛存在于各种生物碱天然产物和药理活性剂中，因此越来越多的有机化学和药物化学研究者投身于构建螺环氧吲哚的优良合成方法.近年来，手性双功能方酰胺催化氧吲哚或者氧吲哚衍生物的不对称串联反应已经成为构建手性螺环氧吲哚的有效合成方法.综述了自2015年以来手性双功能方酰胺催化的不对称串联反应合成螺环氧吲哚衍生物的研究进展，并根据不同的催化反应类型进行分类讨论.

关键词: 螺环氧吲哚, 不对称有机催化, 方酰胺, 串联反应

Chiral spirooxindoles have captured huge attention from researchers in the area of organic chemistry and medicinal chemistry owing to their prevalence in various alkaloid natural products and pharmacologically active agents. In recent year, chiral bifunctional squaramide-catalyzed asymmetric cascade reaction of oxindoles or oxindole derivatives has become an efficient synthetic method for the construction of chiral spirooxindoes. In this review, the remarkable progress and advances in bifunctional squaramide-catalyzed asymmetric cascade reactions for the synthesis of spirooxindole derivatives from 2015 are summarized and discussed based on the different types of catalytic reactions.

Key words: spirooxindoles, asymmetric organocatalysis, squaramides, cascade reactions

引用此文

林晔, 杜大明. 方酰胺催化的不对称串联反应合成螺环氧吲哚衍生物研究进展[J]. 有机化学, 2020, 40(10): 3214-3236.

Lin Ye, Du Daming. Recent Advances in Squaramide-Catalyzed Asymmetric Cascade Reactions for the Synthesis of Spirooxindoles[J]. Chinese Journal of Organic Chemistry, 2020, 40(10): 3214-3236.

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