有机化学 ›› 2020, Vol. 40 ›› Issue (10): 3203-3213.DOI: 10.6023/cjoc202005079 上一篇    下一篇

综述与进展

过渡金属促进的多组分串联反应用于合成复杂碳硼烷衍生物的研究进展

张慧芳a,b, 邱早早b,c, 谢作伟b,d   

  1. a 河南师范大学化学化工学院 河南新乡 453007;
    b 中国科学院上海有机化学研究所 沪港化学合成联合实验室 上海 200032;
    c 中国科学院上海有机化学研究所 中国科学院能量调控重点实验室 上海 200032;
    d 香港中文大学化学系 香港
  • 收稿日期:2020-05-28 修回日期:2020-06-15 发布日期:2020-06-20
  • 通讯作者: 邱早早, 谢作伟 E-mail:qiuzz@sioc.ac.cn;zxie@cuhk.edu.hk
  • 基金资助:
    国家自然科学基金(No.21772223)、上海市科学技术委员会(No.18590760800)、中国科学院、香港研究资助局(No.14306519)资助项目.

Recent Advances in Transition Metal-Promoted Multicomponent Cascade Reactions for Controlled Synthesis of Complex Carborane Derivatives

Zhang Huifanga,b, Qiu Zaozaob,c, Xie Zuoweib,d   

  1. a School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007;
    b Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032;
    c CAS Key Laboratory of Energy Regulation Materials, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032;
    d Department of Chemistry, The Chinese University of Hong Kong, Hong Kong
  • Received:2020-05-28 Revised:2020-06-15 Published:2020-06-20
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21772223), the Science and Technology Commission of Shanghai Municipality (No. 18590760800), the Chinese Academy of Sciences, and the Hong Kong Research Grants Council (No. 14306519).

十二顶点碳硼烷是一类含有碳、氢及硼原子的簇合物,具有特殊的热稳定性和化学稳定性,在医药、材料、能源、配位化学及金属有机化学中都得到广泛的应用.因此,其官能团化成为该领域的研究热点.其中过渡金属介导/催化的多组分串联反应不仅具有高原子经济性的特点,还可以通过简单的原料和简便的操作,不经中间产物分离,以高选择性直接获取复杂产物.总结了近年来过渡金属参与的十二顶点碳硼烷C,C-、C,B-或B,B-顶点通过多组分串联反应高效官能团化的研究进展,同时对部分反应机理进行了讨论,并就该研究领域所面临的挑战和发展前景进行了展望.

关键词: 硼烷簇合物, 碳硼烷, 过渡金属, 官能团化, 串联反应

Carboranes are a class of carbon-boron molecular clusters with exceptional thermal and chemical stabilities. They are finding a variety of applications in medicine, materials, and coordination/organometallic chemistry as functional building blocks. To this end, the selective functionalization of carboranes has received growing research interests. Transition metal-promoted multicomponent cascade reactions are particularly attractive since they have the advantages of step- and atom- economy for the construction of complex products from readily available starting materials by simple operations. The recent advances in transition metal-promoted multicomponent cascade reactions for selective functionalization of carboranes are summarized in this focus review. The related reaction mechanisms and challenges in this research area are also discussed.

Key words: borane cluster, carborane, transition metal, functionalization, cascade reaction