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综述与进展

C,N-环状偶氮次甲基亚胺参与的反应研究进展

华庭碧a,b, 阳青青a,b, 肖文精c   

  1. a 三峡大学天然产物研究与利用湖北省重点实验室 宜昌 443002;
    b 三峡大学材料与化工学院 无机非金属晶态与能源转换材料重点实验室 宜昌 443002;
    c 华中师范大学化学学院 农药与化学生物学教育部重点实验室 武汉 430079
  • 收稿日期:2020-06-30 修回日期:2020-09-04 出版日期:2030-01-01 发布日期:2020-09-16
  • 通讯作者: 阳青青, 肖文精 E-mail:qingqing_yang@ctgu.edu.cn;wxiao@mail.ccnu.edu.cn
  • 基金资助:
    国家自然科学基金(No.21702121)、三峡大学天然产物研究与利用湖北重点实验室开放基金(编号NPRD-2018010)、三峡大学学位论文培优基金和高等学校学科创新引智计划资(D20015)。

Recent Developments of Reactions with C,N-Cyclic Azomethine Imines

Hua Tingbia,b, Yang Qingqinga,b, Xiao Wengjingc   

  1. a Hubei Key Laboratory of Natural Products Research and Development, China Three Gorges University, Yichang 443002) (b College of Materials and Chemical Engineering, Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, China Three Gorges University, Yichang 443002;
    c Key Laboratory of Pesticide & Chemical Biology Ministry of Education and College of Chemistry, Central China Normal University, Wuhan 430079
  • Received:2020-06-30 Revised:2020-09-04 Online:2030-01-01 Published:2020-09-16
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21702121), Open fund from Hubei Key Laboratory of Natural Products Research and Development (China Three Gorges University) (No. NPRD-2018010), Research Fund for Excellent Dissertation of China Three Gorges University and the 111 project (D20015).

在环状偶氮次甲基亚胺类1,3-偶极子中,C,N-环状偶氮次甲基亚胺是最广泛使用的反应试剂,用于结构多样化的四氢异喹啉衍生物的构建。本文简单综述了C,N-环状偶氮次甲基亚胺参与的反应研究进展,重点介绍[3+2]、[3+3]、[3+4]、[5+1]、[3+1]环加成以及其他反应,并讨论反应的特点、反应过程及合成应用,最后展望它的发展前景。

关键词: 1,3-偶极子, 偶氮次甲基亚胺, C,N-环状偶氮次甲基亚胺, 环加成反应, 异喹啉衍生物

Among various 1,3-dipoles of cyclic azomethine imines, C,N-cyclic azomethine imines are the most widely used reagents in the construction of diverse tetrahydroisoquinoline derivatives. This review summarizes the developments of reactions with C,N-cyclic azomethine imines including[3+2],[3+3],[3+4], [5+1],[3+1] cycloaddition reactions and miscellaneous reactions. The properties of reactions, reaction processes and synthetic applications are discussed. Finally, the prospects of the reaction with this reagent are also proposed.

Key words: 1,3-dipole, azomethine imines, C,N-cyclic azomethine imines, cycloaddition reaction, isoquinoline derivatives