有机化学 ›› 2010, Vol. 30 ›› Issue (01): 60-65. 上一篇    下一篇

研究论文

双水相体系中Proline/CuI催化Heck反应的研究

郭圣荣*,袁艳琴,王艳,郑云法   

  1. (丽水学院化学与生命学院 丽水 323000)
  • 收稿日期:2009-02-23 修回日期:2009-04-17 出版日期:2010-01-25 发布日期:2010-01-20
  • 通讯作者: 郭圣荣 E-mail:guosr9608@163.com

Proline/CuI Catalyzed Heck Reaction in Aqueous Two-Phase System

Guo,Shengrong*,Yung,Yanqin,Wang,Yan,Zheng,Yunfa   

  1. (Department of Chemistry,Lishui College,Lishui 323000)
  • Received:2009-02-23 Revised:2009-04-17 Online:2010-01-25 Published:2010-01-20

以双水相为反应溶剂,丙烯酸酯、苯乙烯与多种芳卤化合物在催化剂碘化亚铜、配体L-脯氨酸的存在下,在较低的温度(75~85 ℃)下得到了产物,该方法具有反应时间短、产率较高、选择性较好等特点,为该反应及该类化合物的合成提供了一种新方法。产物通过熔点、红外、核磁共振氢谱、碳谱等方法的表征。

关键词: 双水相体系, Heck反应, 芳基卤化物, L-脯氨酸, 碘化亚铜

The copper-catalyzed Heck reaction of acrylic ester or styrene with aryl halide gave the coupling products in good to excellent yields in aqueous two-phases system in 75~85 ℃ by using L-proline as a ligand。This method provides a new simple and inexpensive access to the Heck reaction。The structures of the products were confirmed by using spectroscopic techniques such as IR,1H NMR,13C NMR and comparing their melting points with known literature.

Key words: aqueous two-phase system, Heck reaction, aryl halide, L-proline, CuI