有机化学 ›› 2018, Vol. 38 ›› Issue (1): 215-220.DOI: 10.6023/cjoc201708009 上一篇    下一篇

所属专题: 庆祝吴养洁院士九十华诞专辑 元素有机化学合辑2018-2019

研究论文

碘/碘化亚铜介导的烯酰胺氧化环化反应合成多取代噁唑

于文全, 常俊标   

  1. 郑州大学化学与分子工程学院 郑州 450001
  • 收稿日期:2017-08-06 修回日期:2017-08-31 发布日期:2017-09-15
  • 通讯作者: 常俊标 E-mail:changjunbiao@zzu.edu.cn
  • 基金资助:

    郑州大学优秀青年人才研究基金(No.1521316004)和国家自然科学基金(No.81330075)资助项目.

I2/CuI-Mediated Oxidative Cyclization of Enamides to Polysubstituted Oxazoles

Yu Wenquan, Chang Junbiao   

  1. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001
  • Received:2017-08-06 Revised:2017-08-31 Published:2017-09-15
  • Contact: 10.6023/cjoc201708009 E-mail:changjunbiao@zzu.edu.cn
  • Supported by:

    Project supported by the Outstanding Young Talent Research Fund of Zhengzhou University (No. 1521316004) and the National Natural Science Foundation of China (No. 81330075).

开发了一种简洁、高效的碘/碘化亚铜介导分子内氧化性C—O键构建反应用于噁唑类化合物的合成.在优化的反应条件下,通过对易得的烯酰胺类底物进行氧化环化可以合成各种芳基、烷基、酰胺基、酯基以及酰基等基团取代的噁唑衍生物.

关键词: 碘, 碘化亚铜, 氧化环化, 烯酰胺, 噁唑

A concise and efficient iodine/copper(I) iodide-mediated intramolecular oxidative C—O bond formation reaction has been developed for oxazole synthesis. Under the optimal reaction conditions, oxidative cyclization of readily accessible enamide substrates provides facile access to a variety of oxazole derivatives bearing aryl, alkyl, amide, ester, and acyl substituents.

Key words: iodine, copper(I) iodide, oxidative cyclization, enamides, oxazoles