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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (01): 124-127. 上一篇    下一篇

研究简报

碱性季铵盐“一锅法”催化合成四氢苯并[b]吡喃的水相反应研究

赵丽琴，李毅群*，陈 路，周 波   

  1. (暨南大学化学系 广州 510632)
  • 收稿日期:2009-05-31 修回日期:2009-07-15 发布日期:2010-01-20
  • 通讯作者: 李毅群 E-mail:tlyq@jnu.edu.cn
  • 基金资助:

    国家级.国家自然科学基金

One-Pot Synthesis of Tetrahydrobenzo[b]pyran Catalyzed by Basic Quaternary Ammonium Salt in Aqueous Medium

Zhao,Liqin，Li,Yiqun*，Chen,Lu，Zhou,Bo   

  1. (Department of Chemistry，Jinan University，Guangzhou 510632)
  • Received:2009-05-31 Revised:2009-07-15 Published:2010-01-20
  • Contact: Li Yi-Qun E-mail:tlyq@jnu.edu.cn

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报道了以2-二甲氨乙基苄基二甲基氯化铵为催化剂，在水相介质中“一锅法”催化芳醛、丙二腈和5,5-二甲基- 1,3-环己二酮合成2-氨基-3-氰基-4-芳基-7,7-二甲基-5-氧代-4H-5,6,7,8-四氢苯并[b]吡喃的方法。该法具有产率高、反应时间短、操作简便、对环境友好、催化剂可重复使用等优点.

关键词: 四氢苯并[b]吡喃, 碱性季铵盐, 2-二甲基氨乙基苄基二甲基氯化铵, 催化, 水相

A synthesis of 2-amino-3-cyano-4-aryl-7,7-dimethyl-5-oxo-4H-5,6,7,8-tetrahydrobenzo[b]- pyrans from aromatic aldehyde，malononitrile and 5,5-dimethyl-1,3-dioxocyclohexane using (2-dimethy- laminoethyl)(benzyl)dimethylammonium chloride ([PhCH2Me2N＋CH2CH2NMe2]Cl－) as catalyst (5 mol%) was described which provided several advantages such as excellent yield，short reaction time，simple ex-perimental and work-up procedure，reusability of catalyst and benignity to environment.

Key words: tetrahydrobenzo[b]pyran, basic quaternary ammonium salt, (2-dimethylaminoethyl)(benzyl)- dimethylammonium chloride, catalysis, aqueous medium