有机化学 ›› 2014, Vol. 34 ›› Issue (5): 994-998.DOI: 10.6023/cjoc201311018 上一篇    下一篇

研究简报

含咔唑基苯并咪唑衍生物的合成

卞垒, 曾向潮, 何如, 罗创龙, 林志强   

  1. 暨南大学化学系 广州 510632
  • 收稿日期:2013-11-13 修回日期:2014-01-20 出版日期:2014-05-25 发布日期:2014-01-24
  • 通讯作者: 曾向潮 E-mail:xczeng@126.com
  • 基金资助:

    广东省大学生创新(No. 1055912003)资助项目.

Syntheses of Benzoimidazole Derivatives Containing Carbazole Unit

Bian Lei, Zeng Xiangchao, He Ru, Luo Chuanglong, Lin Zhiqiang   

  1. Department of Chemistry, Jinan University, Guangzhou 510632
  • Received:2013-11-13 Revised:2014-01-20 Online:2014-05-25 Published:2014-01-24
  • Supported by:

    Project supported by the University Student Innovative Program of Guangdong Province (No. 1055912003).

以咔唑为原料,经烷基化、甲酰化反应合成N-烃基咔唑-3-甲醛;无催化剂条件下,N-烃基咔唑-3-甲醛与邻苯二胺经缩合-环化“一锅”反应合成了两类新型含咔唑单元的苯并咪唑衍生物. 研究了溶剂选择、溶剂用量、反应温度、反应物配比等因素对缩合-环化反应结果的影响;通过改变两种反应物的等物质的量比可选择性地得到以其中一类苯并咪唑衍生物为主的产物.

关键词: 苯并咪唑, 咔唑, 有机合成

Two series of novel benzoimidazole derivatives containing carbazole unit were synthesized via condensation-cyclization of N-alkylcarbazole-3-formaldehyde with 1,2-diaminobenzene in "one pot" reaction without catalyst. The effects of temperature, selection & amount of solvents and molar ratio of the two reagents on the reactions have been investigated; significantly, one of these two series of benzoimidazole derivatives could be prepared as the major products selectively by changing the molar ratio of the two reagents.

Key words: benzoimidazole, carbazole, organic synthesis