有机化学 ›› 2014, Vol. 34 ›› Issue (6): 1048-1060.DOI: 10.6023/cjoc201401030 上一篇    下一篇

综述与进展

2-取代苯并噁唑类化合物合成研究进展

肖立伟, 高红杰, 孔洁, 刘光仙, 彭晓霞, 王树军   

  1. 廊坊师范学院化学与材料科学学院 廊坊 065000
  • 收稿日期:2014-01-19 修回日期:2014-02-20 出版日期:2014-06-25 发布日期:2014-03-12
  • 通讯作者: 肖立伟 E-mail:xiaoliwei2000@sina.com
  • 基金资助:

    河北省自然科学基金(No. B2013408014)和廊坊师范学院重点基金(No. LSZZ201302)资助项目.

Progress in the Synthesis of 2-Substituted Benzoxazoles Derivatives

Xiao Liwei, Gao Hongjie, Kong Jie, Liu Guangxian, Peng Xiaoxia, Wang Shujun   

  1. Faculty of Chemistry and Material Science, Langfang Teachers University, Langfang 065000
  • Received:2014-01-19 Revised:2014-02-20 Online:2014-06-25 Published:2014-03-12
  • Supported by:

    Project supported by the Natural Science Foundation of Hebei Province (No. B2013408014) and the Key Foundation of Langfang Teachers University (No. LSZZ201302).

2-取代苯并噁唑类化合物在医药、农药以及配位催化等领域有广阔的应用前景,因而其合成方法备受关注. 近年来,微波促进、水为介质、无溶剂合成、组合化学以及过渡金属催化等一系列高效、绿色的合成方法在2-取代苯并噁唑类化合物的合成中得到广泛的应用. 按照不同的合成原料和合成方法进行分类,综述了近年来2-取代苯并噁唑类化合物合成研究的新进展.

关键词: 2-取代苯并噁唑, 邻氨基苯酚, 偶联反应, 过渡金属催化, 绿色化学

2-Substituted benzoxazole derivatives play important roles in pharmaceuticals, pesticide and coordination catalysis, so the synthetic methods for 2-substituted benzoxazoles have been attracted widely. Recently, a series of efficient green methods such as microwave irradiation, water as solvent, solvent-free, combinatorial chemistry and transition metal catalysis etc. have been used to synthesize 2-substituted benzoxazoles derivatives. Based on different starting materials and different methods, the recent advances in synthesis of 2-substituted benzoxazole are reviewed.

Key words: 2-substituted benzoxazoles, o-aminophenol, coupled reaction, transition metal catalysis, green chemistry