有机化学 ›› 2015, Vol. 35 ›› Issue (1): 55-69.DOI: 10.6023/cjoc201407032 上一篇    下一篇

综述与进展

Weinreb酰胺在有机合成中的应用进展

赵蔚a, 刘伟b   

  1. a 天津科技大学材料科学与化学工程学院 天津 300457;
    b 天津科技大学理学院 天津 300457
  • 收稿日期:2014-07-19 修回日期:2014-08-28 出版日期:2015-01-25 发布日期:2014-09-16
  • 通讯作者: 刘伟 E-mail:liuwei2006@tust.edu.cn
  • 基金资助:

    国家自然科学基金(No. 21302139)资助项目.

Progresses of Weinreb Amides in Organic Synthesis

Zhao Weia, Liu Weib   

  1. a College of Sciences, Tianjin University of Science & Technology, Tianjin 300457;
    b College of Material Science and Chemical Engineering, Tianjin 300457
  • Received:2014-07-19 Revised:2014-08-28 Online:2015-01-25 Published:2014-09-16
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21302139).

N-甲氧基-N-甲基酰胺, 自从被发现后广泛称为Weinreb酰胺(WAs), 具有与一般酰胺不同的反应特性. 它既可与有机锂或镁试剂反应作为一种优秀酰基化试剂, 又可作为醛基等价体. 由于其作为合成砌块在大量有机合成反应中被使用, 综述了Weinreb酰胺的制备及其新合成应用.

关键词: Weinreb酰胺, 合成砌块, 等价体, 醛, 酮, 格氏试剂

N-Methoxy-N-methylamides, now popularly called Weinreb amides (WAs) after their discovery, have surfaced as amides with a difference. This amide has served as an excellent acylating agent for organolithium or organomagnesium reagents and as an effective equivalent for an aldehyde group. These two aspects have been exploited exhaustively in many synthetic strategies. The growing synthetic utility and preparation of the Weinreb amides are reviewed.

Key words: Weinreb amides, building block, equivalents, aldehydes, ketones, Grignard agent