通过氰基亚胺与香豆灵酸甲酯的1,3-偶极环加成反应合成二氢吡喃并吡唑酮

doi:10.6023/cjoc201810015

摘要/Abstract

室温条件下，氰基亚胺与香豆灵酸甲酯或吡喃酮的[3＋2]环加成反应可高效地进行，以较高至优秀的产率和优秀的非对映选择性生成二氢吡喃并吡唑酮衍生物.

The 1,3-dipolar cycloaddition of nitrilimines with methyl coumalate or pyranone worked efficiently in the presence of ⁱPr₂NEt under room temperature to give functionalized dihydropyrano[3,2-c]pyrazol-5(1H)-one derivatives in high to excellent yields with excellent diastereoselectivities.

Key words: cycloaddition, nitrilimine, coumalate, pyranone, pyrazoline

引用此文

王博, 王奇君, 刘洪蕾, 廖健宁, 黄家兴, 郭红超. 通过氰基亚胺与香豆灵酸甲酯的1,3-偶极环加成反应合成二氢吡喃并吡唑酮[J]. 有机化学, 2019, 39(5): 1354-1361.

Wang Bo, Wang Qijun, Liu Honglei, Liao Jianning, Huang Jiaxing, Guo Hongchao. Synthesis of Dihydropyrano[3,2-c]pyrazolone through 1,3-Dipolar Cycloaddition of Nitrilimines with Methyl Coumalate[J]. Chin. J. Org. Chem., 2019, 39(5): 1354-1361.

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