Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (11): 3084-3104.DOI: 10.6023/cjoc201905027 Previous Articles     Next Articles

Special Issue: 碳氢活化合辑2018-2019



  1. 长江师范学院材料科学与工程学院 重庆涪陵 408100
  • 收稿日期:2019-05-13 发布日期:2019-07-09
  • 通讯作者: 罗飞华
  • 基金资助:

Progress in Transition Metal Catalyzed C-H Functionalization Directed by Carboxyl Group

Luo Feihua*()   

  1. College of Materials Science and Engineering, Yangtze Normal University, Fuling, Chongqing 408100
  • Received:2019-05-13 Published:2019-07-09
  • Contact: Luo Feihua
  • Supported by:
    the Scientific and Technological Research Program of Fuling District Commission(FLKJ);the Scientific and Technological Research Program of Fuling District Commission(2018BBA3039);the Introduction of Yangtze Normal University Scientific Research Grants Project(011160011)

The C-H activation assisted by directing groups is an important measure for selective C-H activation at specific positions, and it is also one of the hot spots in the research field of organic chemistry. As an efficient directing group, carboxylic acid has the advantages of low cost, low toxicity, easy modification and using as traceless directing groups. Recent development on C-H functionalization directed by carboxyl group according to different coupling modes is summarized, and the representative reaction mechanism is briefly described. Existing problems with a brief outlook in this field are also presented.

Key words: catalysis, C-H activation, carboxylic acid, traceless directing group, reaction mechanism