Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (6): 2280-2289.DOI: 10.6023/cjoc202012010 Previous Articles     Next Articles



杨晨, 贾雪锋*()   

  1. 山西师范大学化学与材料科学学院 磁性分子与磁信息材料教育部重点实验室 山西临汾 041000
  • 收稿日期:2020-12-04 修回日期:2021-01-18 发布日期:2021-02-22
  • 通讯作者: 贾雪锋
  • 基金资助:

Recent Advances in Copper-Catalyzed Boron-Reagent-Involved Multicomponent Difunctionalization of Alkenes

Chen Yang, Xuefeng Jia()   

  1. Key Laboratory of Magnetic Molecules & Magnetic Information Materials (Ministry of Education), School of Chemistry and Material Science, Shanxi Normal University, Linfen, Shanxi 041000
  • Received:2020-12-04 Revised:2021-01-18 Published:2021-02-22
  • Contact: Xuefeng Jia
  • Supported by:
    Natural Science Foundation of Shanxi Province(201901D111276)

The multicomponent difunctionalization of alkenes is an important and highly efficient reaction for the rapid construction of molecules with structure diversity, which has some advantanges of high atom economy, wide substrate range as well as mild conditions and becomes the main research hotspot in organic synthesis in recent years. Many examples on the multicomponent difunctionalization of alkenes under metal-catalyzed or metal-free conditions have extentively been reported. Among them, the asymmetric version of some reactions was successfully achieved by the use of chiral ligands. However, compared with nobel metal catalysts such as ruthenium, rhodium, iridium, palladium and silver, the cheaper metal catalysts including iron, cobalt, nickel, copper, manganese have attracted more special attention. In view of the application of copper catalyst and organoboron reagents in organic synthesis, the advances in copper-catalyzed multicomponent difunctionalization of alkenes with organoboron reagents since 2018 are reviewed. The major challenges and development prospects of this fields, including the discovery of new reaction type and organoboron reagents, better stereoselectivity, and deeper understanding on reaction mechanism are also discussed.

Key words: copper-catalysis, boron reagent, alkene, multicomponent difunctionalization