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Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (01): 124-127. Previous Articles     Next Articles

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碱性季铵盐“一锅法”催化合成四氢苯并[b]吡喃的水相反应研究

赵丽琴，李毅群*，陈 路，周 波   

  1. (暨南大学化学系 广州 510632)
  • 收稿日期:2009-05-31 修回日期:2009-07-15 发布日期:2010-01-20
  • 通讯作者: 李毅群 E-mail:tlyq@jnu.edu.cn
  • 基金资助:

    国家级.国家自然科学基金

One-Pot Synthesis of Tetrahydrobenzo[b]pyran Catalyzed by Basic Quaternary Ammonium Salt in Aqueous Medium

Zhao,Liqin，Li,Yiqun*，Chen,Lu，Zhou,Bo   

  1. (Department of Chemistry，Jinan University，Guangzhou 510632)
  • Received:2009-05-31 Revised:2009-07-15 Published:2010-01-20
  • Contact: Li Yi-Qun E-mail:tlyq@jnu.edu.cn

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A synthesis of 2-amino-3-cyano-4-aryl-7,7-dimethyl-5-oxo-4H-5,6,7,8-tetrahydrobenzo[b]- pyrans from aromatic aldehyde，malononitrile and 5,5-dimethyl-1,3-dioxocyclohexane using (2-dimethy- laminoethyl)(benzyl)dimethylammonium chloride ([PhCH2Me2N＋CH2CH2NMe2]Cl－) as catalyst (5 mol%) was described which provided several advantages such as excellent yield，short reaction time，simple ex-perimental and work-up procedure，reusability of catalyst and benignity to environment.

Key words: tetrahydrobenzo[b]pyran, basic quaternary ammonium salt, (2-dimethylaminoethyl)(benzyl)- dimethylammonium chloride, catalysis, aqueous medium