Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (8): 2333-2337.DOI: 10.6023/cjoc201903036 Previous Articles     Next Articles

Special Issue: 陈茹玉先生诞辰100周年

Notes

NaBH4/I2介导的醇的碘化反应

樊正宁a, 张博a, 席婵娟a,b   

  1. a 清华大学化学系 生命有机磷化学及化学生物学教育部重点实验室 北京 100084;
    b 南开大学元素有机化学国家重点实验室 天津 300071
  • 收稿日期:2019-03-20 修回日期:2019-04-17 出版日期:2019-08-25 发布日期:2019-04-26
  • 通讯作者: 席婵娟 E-mail:cjxi@tsinghua.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21871163,91645120)资助项目.

NaBH4/I2-Mediated Efficient Iodination of Alcohols

Fan Zhengninga, Zhang Boa, Xi Chanjuana,b   

  1. a Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084;
    b State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071
  • Received:2019-03-20 Revised:2019-04-17 Online:2019-08-25 Published:2019-04-26
  • Contact: 10.6023/cjoc201903036 E-mail:cjxi@tsinghua.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21871163, 91645120).

A simple, mild, and high yielding procedure for the iodination of alcohols using a combination of NaBH4 and I2 is described. The effectiveness of the protocol is achieved with benzylic alcohols and primary alkylic alcohols whereas allylic and secondary alcohols are found to be unreactive.

Key words: alcohol, iodide, sodium borohydride, iodination