有机化学 ›› 2012, Vol. ›› Issue (03): 462-471.DOI: 10.6023/cjoc1103201 上一篇    下一篇

综述与进展

吲哚与亚胺的Friedel-Crafts 反应的研究进展

陈永诚, 解正峰   

  1. 新疆大学石油天然气精细化工教育部重点实验室 乌鲁木齐 830046
  • 收稿日期:2011-03-20 修回日期:2011-09-17 发布日期:2012-03-24
  • 通讯作者: 解正峰 E-mail:xiezhf72@yahoo.com.cn
  • 基金资助:

    国家自然科学基金(Nos. 20962018, 20862015, 20562011)资助项目.

Research Progress in Friedel-Crafts Reaction of Indoles and Imines

Chen Yongcheng, Xie Zhengfeng   

  1. Key Laboratory of Oil & Gas Fine Chemicals Ministry of Education, Xinjiang University, Urumqi 830046
  • Received:2011-03-20 Revised:2011-09-17 Published:2012-03-24
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 20962018, 20862015, 20562011).

由于吲哚类化合物具有许多生物特性等优点, 在众多天然产物和相应的具有生物活性的化合物中起重要的骨架构筑作用, 其合成方法的研究格外令人注目. 近年来, 关于吲哚与亚胺在催化剂作用下发生Friedel-Crafts 反应来制备3-取代吲哚甲胺衍生物的报道剧增. 对近年来吲哚与亚胺Friedel-Crafts 反应的研究情况进行了综述.

关键词: Friedel-Crafts 反应, 3-取代吲哚甲胺衍生物, 亚胺, 吲哚

Indole derivatives have a variety of merits, which have received much attention as building blocks for the synthesis of many natural products and other biologically active compounds. Recently, there are a lot of reports on the synthesis of 3-indolylmethylamine derivatives via the Friedel-Crafts reaction of indoles and imines. The research progress in these catalytic Friedel-Crafts reactions of indoles and imines is reviewed.

Key words: Friedel-Crafts reaction, 3-indolylmethylamine derivative, imine, indole