有机化学 ›› 2015, Vol. 35 ›› Issue (12): 2552-2558.DOI: 10.6023/cjoc201506024 上一篇    下一篇

研究论文

PhI(OAc)2/I2介导下氮烷氧基酰胺的氧化自身偶联成酯的方法

段希焱a, 段希斌b, 杨坤a, 王志成a, 张璐a, 佟悦a, 刘浩哲a, 杜珂a, 唐榕泽a   

  1. a 河南科技大学化工与制药学院 洛阳 471023;
    b 郑州大学附属郑州中心医院 郑州 450007
  • 收稿日期:2015-06-18 修回日期:2015-07-24 发布日期:2015-08-26
  • 通讯作者: 段希焱 E-mail:duanxiyan@tju.edu.cn
  • 基金资助:

    河南科技大学博士科研启动项目(No. 4008-13480042).

PhI(OAc)2/I2-Mediated Oxidative Homocoupling of N-Alkoxyamides: An Approach to Esters

Duan Xiyana, Duan Xibinb, Yang Kuna, Wang Zhichenga, Zhang Luaa, Tong Yuea, Liu Haozhea, Du Kea, Tang Rongzea   

  1. a School of Chemical Engineering & Pharmaceutics, Henan University of Science and Technology, Luoyang 471023;
    b Zhengzhou Certral Hospital Affiliated to Zhengzhou University, Zhengzhou 450007
  • Received:2015-06-18 Revised:2015-07-24 Published:2015-08-26
  • Supported by:

    Project supported by the Students Research Training Program of Henan University of Science and Technology (No. 4008-13480042).

一系列取代的氮烷氧基酰胺衍生物能够在PhI(OAc)2/I2催化下转化成相应的酯. 这个新颖的合成策略能够有效地合成酯类化合物. 该反应具有原料易得, 反应温和, 底物范围广, 非过渡金属催化等特点.

关键词: 高价碘, 氮烷氧基酰胺, 酯, 氧化偶联

A variety of substituted N-alkoxyamides derivatives were found to be converted to the corresponding esters mediated by PhI(OAc)2/I2. This novel strategy allows for an efficient synthesis of esters and is highlighted by appealing features such as readily available of the starting material, mild reaction condition, wide substrate scope and transition-metal-free characteristics.

Key words: hypervalent iodine, N-alkoxyamides, ester, oxidative coupling