有机化学 ›› 2016, Vol. 36 ›› Issue (4): 673-686.DOI: 10.6023/cjoc201601023 上一篇    下一篇

综述与进展

α-芳基烯基膦酸酯的合成研究进展

施波超a, 方烨汶a, 张莉c, 金小平b, 武永辉a, 方媚a, 杨宇飞a, 陈冲a   

  1. a. 宁波工程学院化学工程学院 宁波 315016;
    b. 浙江医药高等专科学校生物与制药学院 宁波 315100;
    c. 太原理工大学化学化工学院 太原 030024
  • 收稿日期:2016-01-18 修回日期:2016-02-29 发布日期:2016-03-11
  • 通讯作者: 方烨汶, 金小平 E-mail:fang@nbut.edu.cn;jinxp@mail.zjpc.net.cn
  • 基金资助:

    国家自然科学基金(No.21202090)、浙江省自然科学基金(No.LQ13B010004)、国家大学生创新创业训练计划(No.201411058005)、新苗人才计划(No.2015R424004)、宁波市科技创新团队(No.2011B82002)资助项目.

Advances in the Synthesis of α-Aryl Vinylphosphonates

Shi Bochaoa, Fang Yewena, Zhang Lic, Jin Xiaopingb, Wu Yonghuia, Fang Meia, Yang Yufeia, Chen Chonga   

  1. a. School of Chemical Engineering, Ningbo University of Technology, Ningbo 315016;
    b. Department of Biology and Pharmaceutical Sciences, Zhejiang Pharmaceutical College, Ningbo 315100;
    c. College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024
  • Received:2016-01-18 Revised:2016-02-29 Published:2016-03-11
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21202090), the Zhejiang Provincial Natural Science Foundation of China (No. LQ13B010004), the National Training Programs of Innovation and Entrepreneurship for Undergraduates (No. 201411058005), the Xinmiao Talents Program (No. 2015R424004), and the Ningbo Science and Technology Innovation Team (No. 2011B82002).

α-芳基烯基膦酸酯是一类重要的有机磷化合物,并且是合成其它有机磷分子的重要中间体.重点综述了过渡金属催化合成α-芳基烯基膦酸酯的进展,如磷氢化反应、C-C偶联反应和C-P偶联反应等,其它非金属催化条件下的几类合成方法也进行了概述.对α-芳基烯基膦酸酯的有机转化及在膦胺霉素衍生物合成中的应用也进行了探讨.

关键词: α-芳基烯基膦酸酯, 芳基化, 磷氢化反应, 偶联反应

α-Aryl vinylphosphonates are an important class of organophosphorus compounds and synthetic intermediates for other organophosphorus molecules. The progress of transition-metal-catalyzed synthesis of α-aryl vinylphosphonates including hydrophosphorylation reactions, C-C cross-coupling reactions and C-P cross-coupling reactions is reviewed. The synthetic methods under metal-free conditions are also summarized. The organic transformations of α-aryl vinylphosphonates and their applications in the synthesis of fosmidomycin analogues are also highlighted.

Key words: α-aryl vinylphosphonates, arylation, hydrophosphorylation, cross-coupling reaction