有机化学 ›› 2017, Vol. 37 ›› Issue (6): 1537-1541.DOI: 10.6023/cjoc201701009 上一篇    下一篇

研究简报

含吡啶环的3-苯基-1-丙酮肟醚的合成及生物活性

昝宁宁, 万福贤, 王士春, 张君辉, 姜林   

  1. 山东农业大学化学与材料科学学院 泰安 271018
  • 收稿日期:2017-01-04 修回日期:2017-02-12 发布日期:2017-02-27
  • 通讯作者: 姜林 E-mail:jiangl@sdau.edu.cn
  • 基金资助:

    山东省自然科学基金(No.ZR2014BM030)资助项目.

Synthesis and Biological Activity of Novel 3-Phenylpropan-1-one Oxime Ethers Containing Pyridine Moiety

Zan Ningning, Wan Fuxian, Wang Shichun, Zhang Junhui, Jiang Lin   

  1. College of Chemistry and Material Science, Shandong Agricultural University, Taian 271018
  • Received:2017-01-04 Revised:2017-02-12 Published:2017-02-27
  • Contact: 10.6023/cjoc201701009 E-mail:jiangl@sdau.edu.cn
  • Supported by:

    Project supported by the Natural Science Foundation of Shandong Province (No. ZR2014BM030).

为了寻找具有优良杀菌活性的吡啶类农药先导化合物,以3-乙酰吡啶、苯甲醛、取代苯胺、烷氧基胺盐酸盐等为原料,经缩合、加成、肟化反应,合成了一系列结构新颖的含吡啶环的3-苯基-1-丙酮肟醚类化合物,其结构通过IR,1H NMR,13C NMR和元素分析确证.用菌丝生长速率法测定了目标化合物对菌核菌和灰霉菌的离体抑菌活性,结果表明,部分化合物对两种病原菌有很高的活性,其活性甚至高于对照药剂百菌清.

关键词: 杂环化合物, 吡啶, 酮, 肟醚, 生物活性

To search for the pyridine pesticide lead compound with high antigungal activity, a series of novel 3-phenyl propan-1-one oxime ethers bearing pyridine moiety were synthesized using 3-acetypyridine, benzaldehyde, substituted anilines and alkoxyamine hydrochlorides as starting materials. The structures of target compounds were determined by IR, 1H NMR, 13C NMR and elemental analysis. Meanwhile, the target compounds were evaluated for their antifungal activities against S. sclerotiorum and B. cinerea by the mycelium growth rate method. The results indicated that some compounds displayed high antifungal activity to the two kinds of pathogenic fungi, and their activities were even higher than that of the positive control, chlorothalonil.

Key words: heterocycles, pyridine, ketones, oxime ethers, biological activitity