有机化学 ›› 2017, Vol. 37 ›› Issue (8): 1924-1938.DOI: 10.6023/cjoc201703034 上一篇    下一篇

综述与进展

2-位官能团化合成2-取代苯并噻唑的研究进展

戴小强, 朱亚波, 汪洲洋, 翁建全   

  1. 浙江工业大学化学工程学院 杭州 310014
  • 收稿日期:2017-03-20 修回日期:2017-04-09 发布日期:2017-05-04
  • 通讯作者: 翁建全 E-mail:jqweng@zjut.edu.cn
  • 基金资助:

    国家自然科学基金(No.30900959)和浙江省自然科学基金(No.LY17C140003)资助项目.

Progress in 2-Position Functionalized Synthesis of 2-Substitutedbenzothiazoles

Dai Xiaoqiang, Zhu Yabo, Wang Zhouyang, Weng Jianquan   

  1. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014
  • Received:2017-03-20 Revised:2017-04-09 Published:2017-05-04
  • Contact: 10.6023/cjoc201703034 E-mail:jqweng@zjut.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 30900959) and the Natural Science Foundation of Zhejiang Province (No. LY17C140003).

2-取代苯并噻唑类衍生物在化工、医药、农业等领域具有广泛的应用价值.2-位官能团化是合成2-取代苯并噻唑化合物的一种便捷、有效的合成方法.综述了苯并噻唑2-位的烷基化、酰基化、芳基化、胺基化以及磷酸化等产物的合成方法并进行了归类和分析,同时对其发展进行了展望.

关键词: 苯并噻唑, 2-位官能团化, 烷基化, 酰基化, 芳基化, 胺基化, 磷酸化

2-Substitutedbenzothiazole derivatives were widely used in chemical, pharmaceutical and agricultural fields. 2-Position functionalized method was a convenient and effective way to synthesize 2-substitutedbenzothiazoles. In this paper, the methods for the synthesis of 2-substitutedbenzothiazoles by the alkylation, acylation, arylation, amination and phosphorylation reactions at the 2-position are reviewed, and their future outlook is also discussed.

Key words: benzothiazole, 2-position functionalization, alkylation, acylation, arylation, amination, phosphorylation