有机化学 ›› 2018, Vol. 38 ›› Issue (1): 40-50.DOI: 10.6023/cjoc201708006 上一篇    下一篇

所属专题: 庆祝吴养洁院士九十华诞专辑

综述与进展

格氏试剂参与的铁催化偶联反应中的添加物效应(英文)

刘强a, 王彬a, 彭小水a,b, 黄乃正a,b   

  1. a 香港中文大学化学系及合成化学国家重点实验室 香港;
    b 香港中文大学深圳研究院 深圳市药用有机小分子化学合成重点实验室 深圳 518507
  • 收稿日期:2017-08-04 修回日期:2017-09-08 发布日期:2017-09-15
  • 通讯作者: 黄乃正 E-mail:hncwong@cuhk.edu.hk
  • 基金资助:

    国家自然科学基金(No.21672181/21272199)、深圳市科技创新委员会(No.JCYJ20160608151520697)、国家自然基金委与香港研资局联合项目(No.N_CUHK451/13)、香港研资局(Nos.403012/CUHK14309216/CUHK14303815,PolyUC5023-14G)、香港科技创新署资助项目.

Effects of Additives in Iron-Catalyzed Cross-Coupling Reactions Involving Grignard Reagents

Liu Qianga, Wang Bina, Peng Xiaoshuia,b, Wong Henry N. C.a,b   

  1. a Department of Chemistry, The Chinese University of Hong Kong, and State Key Laboratory of Synthetic Chemistry, Hong Kong;
    b Shenzhen Municipal Key Laboratory of Chemical Synthesis of Medicinal Organic Molecules, Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518507
  • Received:2017-08-04 Revised:2017-09-08 Published:2017-09-15
  • Contact: 10.6023/cjoc201708006 E-mail:hncwong@cuhk.edu.hk
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21672181/21272199), the Shenzhen Science and Technology Innovation Committee (No. JCYJ20160608151520697), the National Natural Science Foundation of China and the Research Grants Council of Hong Kong, SAR (RGC) Joint Research Scheme (No. N_CUHK451/13), the RGC (Nos. 403012/CUHK14309216/CUHK14303815, PolyU C5023-14G), and the State Key Laboratory of Synthetic Chemistry and GHP/004/16GD from Innovation and Technology Commission.

铁催化的有机金属亲核试剂与有机卤化物亲电试剂参与的偶联反应是目前形成新的碳碳键的最有效方法之一.综述了最近10年来铁催化的格式试剂参与的偶联反应中有关添加物的相关效应及其影响.

关键词: 铁催化, 偶联反应, 格式试剂, 添加物效应

Iron-catalyzed cross-coupling reactions between organometallic nucleophiles and organic halides as electrophiles represent one of the most powerful methods in the field of carbon-carbon bond construction. This review is concerned with the additive effect in iron-catalyzed cross-coupling reactions of Grignard reagents, whose results were published in recent years.

Key words: iron-catalyzed, cross-coupling, Grignard reagents, additive effect