有机化学 ›› 2022, Vol. 42 ›› Issue (4): 1033-1060.DOI: 10.6023/cjoc202110026 上一篇    下一篇

综述与进展

过渡金属催化偕二溴烯烃衍生物的偶联反应

梁陆祺a,b, 张立志b,*(), 彭永利a,*(), 刘会a,b,*()   

  1. a 武汉工程大学材料科学与工程学院 武汉 430205
    b 山东理工大学化学与工程学院 山东淄博 255049
  • 收稿日期:2021-10-19 修回日期:2021-12-03 发布日期:2021-12-22
  • 通讯作者: 张立志, 彭永利, 刘会
  • 基金资助:
    国家自然科学基金(22078178); 山东省青年创新团队引育计划资助项目.

Transition-Metal Catalyzed Coupling Reactions of gem-Dibromovinyl Derivatives

Luqi Lianga,b, Lizhi Zhangb(), Yongli Penga(), Hui Liua,b()   

  1. a School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205
    b School of Chemical Engineering, Shandong University of Technology, Zibo, Shandong 255049
  • Received:2021-10-19 Revised:2021-12-03 Published:2021-12-22
  • Contact: Lizhi Zhang, Yongli Peng, Hui Liu
  • Supported by:
    National Natural Science Foundation of China(22078178); Youth Innovative Talents Attracting and Cultivating Plan of Colleges and Universities in Shandong Province.

偕二溴烯烃衍生物是有机化学中非常重要的合成工具, 已被广泛应用于功能化分子的构建. 在过去几十年中, 金属催化(如铂、铜、银、金、镍)与偕二溴烯烃衍生物的转化已发展成为合成炔烃、色烯、吲哚、苯并吲哚及苯并噻吩等具有重要生理活性的苯并稠合杂环的有力工具. 总结了自2013年以来过渡金属催化的偕二溴烯烃衍生物转化的研究进展.

关键词: 偕二溴烯烃衍生物, 炔基中间体, 过渡金属催化, 偶联反应

gem-Dibromovinyl derivatives are valuable synthetic tools in organic chemistry, which have been widely applied in the construction of founctionalized molecules. In the past few years, metal-catalyzed (such as Pd, Cu, Ag, Au and Ni) transformations with gem-dibromovinyl derivatives have been developed and become a powerful tool for the synthesis of alkynes, chromenes, indoles, benzindole, benzothiophene and other benzo-fused heterocycles with important physiological activity. The progresses in transition-metal-catalyzed transformations of gem-dibromoviny derivatives since 2013 are summarized.

Key words: gem-dibromovinyl derivative, alkynyl intermediate, transition metal catalysis, coupling reaction