有机化学 ›› 2017, Vol. 37 ›› Issue (12): 3257-3261.DOI: 10.6023/cjoc201709043 上一篇    下一篇

研究简报

阳离子镱化合物催化合成2-氨基苯并噻嗪

冯善娥, 花露, 姚志刚, 徐凡   

  1. 苏州大学材料与化学化工学部 苏州 215123
  • 收稿日期:2017-09-26 修回日期:2017-10-23 发布日期:2017-11-15
  • 通讯作者: 徐凡 E-mail:xufan@suda.edu.cn
  • 基金资助:

    国家自然科学基金(No.21272168)资助项目.

Syntheses of 2-Amino-3,1-benzothiazines Catalyzed by Cationic Ytterbium Complex

Feng Shan'e, Hua Lu, Yao Zhigang, Xu Fan   

  1. College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123
  • Received:2017-09-26 Revised:2017-10-23 Published:2017-11-15
  • Contact: 10.6023/cjoc201709043 E-mail:xufan@suda.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21272168).

2-氨基苯并噻嗪及其官能化衍生物具有丰富生物活性,因此发展其高效合成方法受到了众多化学家的关注.以阳离子型镱化合物[Yb(CH3CN)9]3+[(AlCl43]3-·CH3CN可催化邻氨基肉桂酸乙酯与异硫氰酸酯的反应,在无溶剂条件下以高收率合成得到了一系列2-氨基苯并噻嗪化合物.该方法使用的催化剂用量低,反应条件温和,同时具有良好的化学选择性.

关键词: 阳离子化合物, 镱, 催化, 2-氨基苯并噻嗪

2-Amino-3,1-benzothiazine and its functionalized derivatives are known as useful compounds with a range of biological applications. A highly efficient reaction of o-aminocinnamate and isothiocyanates catalyzed by cationic ytterbium complex[Yb(CH3CN)9]3+[(AlCl4)3]3-·CH3CN under mild and solvent-free conditions was developed, which provides 2-amino-3,1-benzothiazines in high yields and chemoselectivity.

Key words: cationic complex, ytterbium, catalysis, 2-amino-3,1-benzothiazine