有机化学 ›› 2019, Vol. 39 ›› Issue (3): 625-647.DOI: 10.6023/cjoc201808031 上一篇    下一篇

综述与进展

烯烃的双官能团化反应研究进展

付晓飞a, 赵文献a,b   

  1. a 郑州大学化学与分子工程学院 郑州 450000;
    b 商丘师范学院化学化工学院 商丘 476000
  • 收稿日期:2018-08-27 修回日期:2018-11-01 发布日期:2018-11-26
  • 通讯作者: 赵文献 E-mail:zhwx2595126@163.com
  • 基金资助:

    国家自然科学基金(Nos.20972091,21172139)、河南省高等学校重点科研(No.16A150020)资助项目.

Progress in Difunctionalization of Alkenes

Fu Xiaofeia, Zhao Wenxiana,b   

  1. a College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450000;
    b College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000
  • Received:2018-08-27 Revised:2018-11-01 Published:2018-11-26
  • Contact: 10.6023/cjoc201808031 E-mail:zhwx2595126@163.com
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 20972091, 21172139) and the Key Science Research of Education Committee in Henan Province (No. 16A150020).

作为一类重要的有机化学反应,烯烃的双官能团化反应不仅可以经济有效地一步合成多位点反应产物,而且可以将起始原料转化为多种含有生物活性或药物活性的化合物,同时还为构建化学结构的多样性提供了更多的方法,所以发展烯烃的双官能团化反应十分重要.对近十二年来各类烯烃的双官能团化反应进行了综述.主要分为:铜催化的烯烃的双官能团化反应、其它过渡金属催化的烯烃的双官能团化反应以及非金属催化的烯烃的双官能团化反应.同时对该类反应的发展前景进行了展望.

关键词: 烯烃, 双官能团化, 催化

As an important kind of organic chemical reaction, difunctionalization of alkenes can not only synthesize multi-site reaction products effectively in one step, but also transform the starting material into other compounds that containing biological activity or drug activity. At the same time, it provides more methods for the construction of chemical structure diversity, so it is very important to develop the bifunctionalization of alkenes. In this paper, the bifunctionalization of various alkenes in recent 12 years is reviewed. It can be divided into three parts:copper-catalyzed difunctionalization of alkenes, other transition metal-catalyzed difunctionalization of alkenes, and non-metal-catalyzed difunctionalization of alkenes. The prospects of this reaction are also discussed.

Key words: alkene, bifunctionalization, catalysis