有机化学 ›› 2020, Vol. 40 ›› Issue (6): 1461-1472.DOI: 10.6023/cjoc202001004 上一篇    下一篇

综述与进展

基于过渡金属-O弱配位的C(sp2)—H直接烯基化反应进展

尹彪, 付曼琳, 朱勍   

  1. 浙江工业大学生物工程学院 浙江省生物有机合成重点实验室 杭州 310014
  • 收稿日期:2020-01-02 修回日期:2020-03-10 发布日期:2020-03-31
  • 通讯作者: 朱勍 E-mail:zhuq@zjut.edu.cn
  • 基金资助:
    浙江省自然科学基金(No.LY17B060009)资助项目.

Recent Advances in Transition Metal-O Weak Coordinated C(sp2)—H Direct Alkenylation Reaction

Yin Biao, Fu Manlin, Zhu Qing   

  1. Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014
  • Received:2020-01-02 Revised:2020-03-10 Published:2020-03-31
  • Supported by:
    Project supported by the Natural Science Foundation of Zhejiang Province (No. LY17B060009).

过去几十年中,碳氢官能团化反应由于其反应高效简单、原子经济性高等特点,成为近年来化学家们研究的热点之一.在此类反应中,过渡金属与氧原子之间的弱配位作用已经成为芳烃的C(sp2)-H烯基化反应的重要策略.综述了近年来过渡金属催化的具有含氧官能团(羟基、芳基醚、醛基、羰基、羧基、酰胺、磷酸和磺酸及其衍生物)的芳烃C(sp2)-H烯基化反应,并展望了其未来发展趋势.

关键词: 碳氢官能团化, 过渡金属, 弱配位, 烯基化

Over the past decade, the C(sp2)-H functionalization has emerged as a powerful methodology due to its high efficiency, simplicity, and high atomic economy. Among them, weak coordination between transition metal and oxygen atom has become an important strategy for C(sp2)-H alkenylation of arenes. In this paper, the transition metal-catalyzed C(sp2)-H alkenylation of substrates containing hydroxy, aryl ether, aldehyde, carbonyl, carboxyl, amide, phosphoric acid and sulfonic acid and their derivatives groups is reviewed, and its future development trends are prospected.

Key words: C(sp2)-H functionalization, transition metal, alkenylation, weak coordination