有机化学 ›› 2025, Vol. 45 ›› Issue (8): 2773-2795.DOI: 10.6023/cjoc202412012 上一篇    下一篇

综述与进展

CO替代物参与羰基化反应研究进展

冯保林, 王鹏,*(), 赵德明, 杨桂爱, 晏耀宗, 史会兵, 王耀伟   

  1. 山东京博石油化工有限公司 山东滨州 256500
  • 收稿日期:2025-01-15 修回日期:2025-02-10 发布日期:2025-03-07
  • 作者简介:

    †共同第一作者.

  • 基金资助:
    国家自然科学基金(21901250)

Research Progress on CO Surrogates in Carbonylation Reactions

Baolin Feng, Peng Wang*(), Deming Zhao, Guiai Yang, Yaozong Yan, Huibing Shi, Yaowei Wang   

  1. Shandong Chambroad Petrochemicals Co., Ltd, Binzhou, Shandong 256500
  • Received:2025-01-15 Revised:2025-02-10 Published:2025-03-07
  • Contact: *E-mail:lzuwangpeng@163.com
  • About author:

    †These authors contributed equally to this work.

  • Supported by:
    National Natural Science Foundation of China(21901250)

羰基化反应产物中的“羰基”官能团通常来源于气体一氧化碳(CO)或者其替代物. 气体CO作“羰源”虽然底物普适性广泛, 可实现工业化放大生产, 但其本身有毒且易燃; CO替代物的化学性质稳定且容易获得, 反应过程易于操作且分离后处理简单. 因此, 借助CO替代物实现羰基化转化, 为构建多种化学品提供了一系列强大且前景广阔的工具. 总结和讨论了使用CO替代物(二氧化碳、氯仿、羧酸及羧酸衍生物、羰基金属试剂、酰氯类化合物等)作为羰源合成高附加值化学品的最新进展, 展望了不同羰源在羰基化反应中的发展前景以及存在的难点, 以期为推动研制更多新型的CO替代物提供借鉴.

关键词: 羰基化反应, 一氧化碳替代物, 二氧化碳, 氯仿, 羧酸衍生物, 羰基金属试剂, 酰氯

The “carbonyl” functional group of the products in carbonylation reactions usually comes from gas carbon monoxide (CO) or its surrogates. Although gas CO as carbonyl source has wider substrate scope and can achieve industrial production, it is toxic and flammable. CO surrogates have stable chemical properties, which are easy to obtain. The reaction process is easy to operate and the separation/post-treatment is simple. Therefore, CO surrogates provide a variety of powerful and promising tools for the carbonylative conversion and construction of diverse chemicals. This review summarizes and discusses the latest progress in synthesizing high value-added chemicals using CO surrogates (carbon dioxide, chloroform, carboxylic acids and their derivatives, carbonyl metal reagents, acyl chlorides, etc.) as carbonyl sources. Finally, the development prospects and existing difficulties of different carbonyl sources in carbonylation reactions were discussed, in order to provide reference for promoting the development of more novel CO surrogates.

Key words: carbonylation, CO surrogates, carbon dioxide, chloroform, carboxylic acid derivatives, carbonyl metal reagent, acyl chloride