关键词: 过渡金属催化, 自由基, 1,3-二烯, 双官能团化, 选择性

In recent years, the rapid advancement of radical chemistry and its deep integration with transition metal catalysis have established a powerful new paradigm for the efficient construction of complex molecules in organic synthesis. Compared with traditional ionic reactions, radical reactions offer unique advantages such as mild reaction conditions, good functional group compatibility, and the ability to rapidly build molecular complexity, which have garnered sustained attention from synthetic chemists. 1,3-Dienes, as a class of readily available and structurally diverse building blocks, are widely embedded in natural products and functional molecules, and their selective difunctionalization remains a significant challenge and an active area of research. Radical-based strategies, particularly when synergized with transition metal catalysis, not only overcome the limitations of conventional polar reactivity, but also unlock novel chemical space, enabling the one-pot, simultaneous incorporation of two distinct functional groups to afford high-value allylic compounds with precision. A systematic overview of key advances over the past three years is provided. Emphasis is placed on the development of diverse transition metal catalysts, innovative radical precursors, evolving mechanistic understanding, and representative catalytic systems. Through illustrative examples, their synthetic applications and future potential are further discussed, aiming to offer both conceptual insights and practical guidance to inspire continued innovation in this dynamic field.

Key words: transition metal catalysis, radical, 1,3-diene, difunctionalization, selectivity