可见光/铬协同催化的对映选择性转化反应研究进展

doi:10.6023/cjoc202512018

摘要/Abstract

光氧化还原催化与第一过渡系金属催化的协同融合,已经有力推动了可持续不对称合成的发展。其中,光氧化还原催化剂与铬催化剂的结合尤为引人注目。铬作为一种储量丰富且具有丰富单/双电子氧化还原特性的金属,可实现新颖的反应模式与立体控制策略。本综述评述了近年来通过可见光/铬协同催化实现的对映选择性转化的研究进展,分析了各组分的独特作用、协同机制及手性活化模式,涵盖了对映选择性自由基加成、C-H键官能团化、交叉偶联及多组分反应等关键转化。最后,本综述指出了这一快速发展领域当前面临的挑战与未来的机遇,并强调其在推动更可持续的药物及农用化学品生产方面的潜力。

关键词: 可见光, 铬, 对映选择性, 不对称, 光氧化还原, 金属光氧化还原, 自由基

The synergistic merger of photoredox catalysis with first-row transition metal catalysis has enabled a powerful development for sustainable asymmetric synthesis. Among these, the combination of photoredox catalysts with chromium complexes—an abundant metal with rich one- and two-electron redox chemistry—has unlocked novel reactivity manifolds and stereocontrol strategies. This review examines the recent advances in enantioselective transformations enabled by synergistic photocatalytic/chromium catalysis. We analyzed the unique catalyst roles, synergistic mechanisms, and activation modes, covering key transformations such as enantioselective radical addition, C-H functionalization, cross-coupling, and multicomponent reactions. Allylic, propargylic and alkylic radical involved transformations that are enabled by the dual photoredox/chromium catalysis were discussed respectively. The evolution of this field is summarized, highlighting strategies to broaden substrate scope and develop novel pathways for accessing diverse structures. The review concludes by highlighting current challenges and future opportunities for this rapidly evolving field, emphasizing its potential for more sustainable pharmaceutical and agrochemical manufacturing.

Key words: visible light, chromium, enantioselective, asymmetric, photoredox, metallophotoredox, radical

引用此文

缪宇辰, 杞航, 黄焕明. 可见光/铬协同催化的对映选择性转化反应研究进展[J]. 有机化学, doi: 10.6023/cjoc202512018.

Yu-Chen Miao, Hang Qi, Huan-Ming Huang. Recent Advances in Enantioselective Transformations Enabled by Synergistic Photoredox/Chromium Catalysis[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202512018.

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