SIOC English
有机化学
高级检索

有机化学    

研究论文

FeCl3催化的含吡唑骨架与叔醇酯基杂环化合物的构建

谢速, 赵志飞*, 李师伍*   

  1. 石河子大学化学化工学院/化工绿色过程省部共建国家重点实验室培育基地 新疆石河子 832000
  • 收稿日期:2026-01-16 修回日期:2026-02-25

FeCl3-Mediated Assembly of heterocyclic compounds containing both pyrazole scaffolds and tertiary alcohol ester moieties

Xie Su, Zhao Zhifei*, Li Shi-Wu*   

  1. School of Chemistry and Chemical Engineering, Shihezi University/State Key Laboratory Incubation Base for Green Processing of Chemical Engineering Shihezi, Xinjiang 832000
  • Received:2026-01-16 Revised:2026-02-25
  • Contact: *E-mail: lishiwu@shzu.edu.cn, zhaozf@shzu.edu.cn
  • Supported by:
    Science and Technology Program of XPCC (No. 2023CB008-19), National Natural Science Foundation of China (No. 22461036 and No. 22101188).

PDF

39

补充材料

1

我们报道了一种绿色合成方法,通过廉价易得FeCl₃催化构建含吡唑骨架与叔醇酯基的杂环化合物。该方法底物范围广、官能团耐受性高、操作简便,产率达82%-98%。此外,放大实验及产物的合成转化（包括上市药物的修饰）进一步凸显了其实用性。

关键词: 吡唑骨架, 三氯化铁催化, 杂环化合物, 叔醇, 生物活性杂环化合物

Herein, we report a green synthetic method for the construction of heterocyclic compounds bearing a pyrazole core and a tertiary alcohol ester moiety, catalyzed by inexpensive and readily available FeCl₃. This method features a broad substrate scope, high functional group tolerance, and operational simplicity, with yields ranging from 82% to 98%. Furthermore, the practicality of this protocol is highlighted by scale-up experiments and synthetic transformations of the products, including the modification of marketed drugs.

Key words: Pyrazole scaffold, FeCl3 catalysis, Heterocyclic compounds, Tertiary alcohol, Bioactive heterocycles