有机化学 ›› 1990, Vol. 10 ›› Issue (5): 445-447. 上一篇    下一篇

研究论文

氰醇碳酸脂的制备及作为酰基负离子等效剂的应用

陈祖兴   

  1. 湖北大学化学系
  • 发布日期:1990-10-25

The preparation o cyano-carbonates and its application as acylanion equivalents

CHEN ZUXING   

  • Published:1990-10-25

本文参考前人的工作, 在相转移催化剂的作用下, 以高产率制得了氰醇碳酸脂, 并以其为酰负离子的等效剂, 与R-X作用合成了一系列酮。

关键词: 红外分光光度法, 相转移催化剂, 气相色谱, 碳酸 P, 羧酸酯, 醇, 质子磁共振谱法, 亲核反应, 氰化合物,

Cyano carbonates, conveniently prepared in excellent yield by in situ trapping of cyanohydrin anions with chloroformates under phase transfer catalytic conditions, have been found to be efficient acyl-anion equivs. The alkylation of a-cyano carbonate afforded a convenient method for aldehyde-ketone conversion. E.g., alkylation of PhCH(CN)OCO2Et, obtained from PhCHO, with MeI gave 71% acetophenone.

Key words: GAS CHROMATOGRAPHY, INFRARED SPECTROPHOTOMETRY, CARBOXYLIC ACID ESTER, PHASE TRANSFER CATALYST, CARBONIC ACID P, ALCOHOL, PROTON MAGNETIC RESONANCE SPECTROMETRY, CYANOGEN COMPOUNDS, NUCLEOPHILIC REACTION, KETONE

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