有机化学 ›› 2001, Vol. 21 ›› Issue (1): 1-7. 上一篇    下一篇

研究论文

氮杂Wittig反应的最近进展

丁明武;刘钊杰   

  1. 华中师范大学有机合成研究所.武汉(430070)
  • 发布日期:2001-01-25

Recent advances in Aza-Wittig reaction

Ding Mingwu;Liu Zhaojie   

  1. Huazhong Normal Univ, Inst Organ Synth.Wuhan(430070)
  • Published:2001-01-25

综述了最近几年氮杂Wittig反应的研究进展,包括分子间氮杂Wittig反应、分子内氮杂wittig反应及串联的氮杂Wittig反应。讨论了氮杂Wittig反应在一些含氮杂环、稠杂环及天然产物合成中的应用。

关键词: 有机合成, 维蒂希反应, 稠环化合物, 氮杂环化合物, 分子间反应, 分子内反应

Recent advances in aza-Wittig reaction, including intermolecular, intramolecular and tandem ones, are reviewed. The application of the aza-Wittig reactions in synthesis of some N-heterocycles, fused heterocycles and natural products are also discussed. Some N- containing compounds not easily accessible by other methods were prepared by intermolecular aza-Wittig reactions under mild neutral conditions. The effcient intramolecular aza-Wittig reaction was also successively utilized in synthesis of five to eight-membered heterocycles, including some optically active natural compounds. Many heterocycles, fused heterocycles and natural compounds were prepared via the versatile tandem aza-Wittig reaction, such as tandem aza- Wittig/heterocumulene- mediated annulation, three component tandem aza- Wittig reaction, tandem aza-Wittig/electrocyclic ring closure, tandem aza-Wittig/ hetero-Diels-Alder closure and tandem aza-Wittig reaction utilizing bis-iminophosphorane.

Key words: ORGANIC SYNTHESIS, WITTIG REACTION, FUSED RING COMPOUNDS, NITROGEN HETEROCYCLICS, INTERNAL MOLECULAR REACTION

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