有机化学 ›› 2003, Vol. 23 ›› Issue (10): 1111-1113. 上一篇    下一篇

研究论文

蛋氨酸合成酶催化反应研究VII.5-氨基-6-甲基尿嘧啶的合成研究

韩鹏;王孝伟;张志丽;陈林丽;刘俊义   

  1. 北京大学药学院化学生物学系;山西省长治卫校
  • 发布日期:2003-10-25

Study on the Catalytic Reaction of Methionine Synthase VII. Synthesis of 5-Amino-6-methyluracil

Han Peng;Wang Xiaowei;Zhang Zhili;Liu Junyi   

  1. Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University
  • Published:2003-10-25

报道了5-氨基-6-甲基尿嘧啶简便的合成方法。该化合物以6-甲基尿嘧啶(2) 为起始物,经硝化或重氮化分别得到了中间体5-硝基-6-甲基尿嘧啶(3)和5-偶氮 苯基-6-甲基尿嘧啶(4),化合物3和4经Na_S_2O_4还原,合成产物5-氨基-6-甲基尿 嘧啶(1)。

关键词: 尿嘧啶 P, 苯偶氮化合物, 硝化作用, 重氮化

5-Amino-6-methyluracil is a key intermediate compound of methionine synthase inhibitors, which can be synthesized from 6-methyuracil through two methods: (a) by reduction of 5-nitro-6-methyluracil and (b) by reduction of 5-phenylazo-6-methyluracil. Some modifications were made and a convenient procedure has been developed.

Key words: URACIL P, BENZENE AZO COMPOUNDS, NITRIFICATION, DIAZOTIZATION

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