有机化学 ›› 2004, Vol. 24 ›› Issue (5): 521-524. 上一篇    下一篇

研究论文

1,3-偶极环加成合成新型4,5-二氢-2',5'-二氧杂吡咯啉并[4,5-c]异噁唑衍生物

刘方明*,a, 邓莉平b, 邬继荣a, 文娜b, 王厚勇b   

  1. a杭州师范学院化学系 杭州 310012
    b新疆大学化学与化工学院 乌鲁木齐 830046
  • 收稿日期:2003-07-17 接受日期:2003-11-25 发布日期:2022-09-20
  • 基金资助:
    国家自然科学基金(Nos. 29702007, 20162004)资助项目.

Synthesis of New 4,5-Dihydro-2',5'-dioxo-pyrrolino[4,5-c]isoxazole Derivatives by 1,3-Dipolar Cycloaddition Reaction

LIU, Fang-Ming*,a, DENG, Li-Pingb, WU, Ji-Ronga, WEN, Nab, WANG, Hou-Yongb   

  1. aDepartment of Chemistry, Hangzhou Teachers College, Hangzhou 310012
    bCollege of Chemistry and Chemical Engineering, Xinjiang University, Ulumqi 830046
  • Received:2003-07-17 Accepted:2003-11-25 Published:2022-09-20
  • Contact: *E-mail: fmliu895@sohu.com

N-取代苯基马来酰亚胺与α-氯代-1,2,3-三唑-4-甲醛肟和α-氯代-喹喔啉-2-甲醛肟在三乙胺作用下通过1,3-偶极环加成合成了一系列4,5-二氢-2',5'-二氧杂吡咯啉并[4,5-c]异噁唑衍生物.化合物结构经元素分析,IR, 1H NMR及MS得到确证.

关键词: 喹喔啉, 1,2,3-三唑, 吡咯啉并[4,5-c]异噁唑, 1,3-偶极环加成

Two series of new 4,5-dihydro-2',5'-dioxo-pyrrolino[4,5-c]isoxazoles have been synthesized by the reactionof N-arylmaleimides with nitrile oxide, prepared from 1,2,3-triazoly-4-hydroximoyl chloride and quinoxalinyl-2-hydroximoyl chloride in situ through 1,3-dipolar cycloaddition reaction. The structures of all new compounds were confirmed by elemental analysis, IR, 1H NMR and MS spectral data.

Key words: quinoxaline, 1,2,3-triazole, pyrrolino[4,5-c]isoxazole, 1,3-dipolar cycloaddition