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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (02): 261-265. 上一篇    下一篇

研究简报

水中2,4,6-三芳基-3-芳酰基-4-羟基环己基-1,1-二甲腈的洁净合成

靳通收*，尹影，刘利宾，赵莹，李同双   

  1. (河北大学化学与环境科学学院 保定 071002)
  • 收稿日期:2006-05-08 修回日期:2006-06-21 发布日期:2007-01-30
  • 通讯作者: 靳通收

Clean Synthesis of 3-Aroyl-2,4,6-triaryl-4-hydroxycyclohexane-1,1-dicarbonitrile in Aqueous Media

JIN Tong-Shou*, YIN Ying, LIU Li-Bin, ZHAO Ying, LI Tong-Shuang   

  1. (College of Chemistry and Environmental Science, Hebei University, Baoding 071002)
  • Received:2006-05-08 Revised:2006-06-21 Published:2007-01-30
  • Contact: JIN Tong-Shou

PDF

846

被引次数

3

研究了十六烷基三乙基溴化铵(HTEAB)催化、水介质中, 查尔酮和丙二腈加热回流合成系列2,4,6-三芳基-3-芳酰基-4-羟基环己基-1,1-二甲腈化合物. 产物经1H NMR, IR和元素分析进行了结构表征. 此方法具有反应条件温和、操作简便、产率较高、环境友好的优点.

关键词: 丙二腈, 水介质, 绿色合成, 2,4,6-三芳基-3-芳酰基-4-羟基环己基-1,1-二甲腈, 查尔酮

A series of 3-aroyl-2,4,6-triaryl-4-hydroxycyclohexane-1,1-dicarbonitriles were synthesized from chalcones and malononitrile catalyzed by hexadecyltriethyl ammonium bromide (3 mol%) in aqueous media. The structures of all products were characterized by 1H NMR, IR spectra and elemental analysis. This method provides several advantages such as mild conditions, simple work-up procedure, high yields and environment friendliness. In addition, water was chosen as a green solvent.

Key words: malononitrile, aqueous media, chalcone, clean synthesis, 3-aroyl-2,4,6-triaryl-4-hydroxycyclohexane-1,1-dicarbonitrile