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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (03): 383-386. 上一篇    下一篇

研究简报

紫草素类似物全合成研究

李娟1,2，章军1，荆文光1，李旭琴*,1，陈胜璜2，刘安*,1   

  1. (1中国中医科学院中药研究所 北京 100700)
    (2湖南中医药大学药学院 长沙 410208)
    (3北京科技大学化学与生物工程学院 北京 100083)
  • 收稿日期:2010-04-30 修回日期:2010-08-16 发布日期:2010-10-15
  • 通讯作者: 刘安 E-mail:la62@163.com
  • 基金资助:

    中国中医科学院自选课题

Studies on the New Synthetic Method of Shikonin Analogues

Li Juan1,2 Zhang Jun1 Jin Wen-guang1 Li Xuqin*,1, Chen Shenghuang2 Liu An*,1   

  1. (1 Institute of Chinese Materia Medica， China Academy of Chinese Medical Sciences, Beijing 100700)
    (2 School of Pharmaceutical Science, Hunan University of Chinese Medicine, Changsha 410208 )
    (3 School of Chemical and Biological Engineering, Uinversity of Science and Technology, Beijing 100083)
  • Received:2010-04-30 Revised:2010-08-16 Published:2010-10-15
  • Contact: An Liu E-mail:la62@163.com

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被引次数

4

以1,4-二氢基萘醌为原料, 经过甲基化、甲酰化、NHK (Nozaki-Hiyama-Kishi)反应、硝酸铈铵(CAN)和AgO/HNO3氧化脱甲氧基等5步反应, 完成了一条紫草素类似物新的合成路线. 该路线能够简便、快速地合成紫草素类似物.

关键词: 紫草素类似物, 全合成, NHK反应

The new synthetic route of shikonin analogues was finished in five reaction steps including methylation, formylation, NHK (Nozaki-Hiyama-Kishi) reaction, protection of oxidative demethoxylation, using 1,4-dihydro-naphthoquinone as the starting material. The route is simple and rapid for synthesizing shikonin analogues.

Key words: shikonin analogue, new synthetic method, NHK reaction