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有机化学
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有机化学 ›› 1993, Vol. 13 ›› Issue (2): 162-165. 上一篇    下一篇

研究论文

芳香杂环并吡咯的合成和在天然产物全合成中的应用

沙晋康;蔡琮莹   

  1. 台湾清华大学化学系
  • 发布日期:1993-04-25

Syntheses of iso-condensed heteroaromatic pyrroles and the application to the total syntheses of natural products

SHA JINKANG;CAI CONGYING   

  • Published:1993-04-25

叠氮基-丙二酸烷叉酯的分子内1,3-二极环加成和环翻转反应被用于制备异缩合杂环芳香吡咯的新方法, 报导了这一方法用于合成2,4-二氢吡咯[3,4-b]吲哚环系, 同样这一环系被用于椭园玫瑰树碱的全合成。

关键词: 环翻转反应, 生物碱, 天然产物, 叠氮化物, 椭园玫瑰树碱, 环加成反应, 全合成, 烷叉, 丙二酸酯

A novel method, namely the intramolecular 1,3-dipolar cycloaddition and cycloreversion of azido-alkylidene malonates, for the preparation of iso-condensed heteroaromatic pyrroles has been developed. The application of this methos for the synthesis of 2,4-dihydropyrrolo[3,4-b]indole ring system, as well as the application of this ring system for the total syntheses of ellipticine alkaloids are reported.

Key words: AZIDE, ALKALOID, NATURAL PRODUCTS, CYCLOADDITION REACTION, TOTAL SYNTHESIS, ALKYLIDENE, MALONIC ESTER

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